Clinical perspective of RANK/RANKL/OPG system components in rheumatoid arthritis

Authors: Gažová Andrea 1;  Kužma Martin 2;  Killinger Zdenko 2;  Payer Juraj 2;  Kyselovič Ján 2
Authors‘ workplace: Ústav farmakológie a klinickej farmakológie, LF UK, Bratislava, Slovensko 1;  V. interná klinika, LF UK a UNB, Nemocnica Ružinov, Bratislava, Slovensko 2
Published in: Clinical Osteology 2018; 23(4): 176-180


Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory autoimmune disease affecting mainly synovial tissue as its primary target. Uncontrolled disease activity causes not only joint destruction but is associated with increased mortality mainly due to cardiovascular involvement. Understanding the role of cytokines in patophysiology of RA and their link to cardiovascular system could contribute to cardiovascular risk markers detection in RA patients.


cardiovascular system – NF-κB signal system – RANK/RANKL/OPG – rheumatoid arthritis

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Clinical biochemistry Paediatric gynaecology Paediatric radiology Paediatric rheumatology Endocrinology Gynaecology and obstetrics Internal medicine Orthopaedics General practitioner for adults Radiodiagnostics Rehabilitation Rheumatology Traumatology
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