Current perspectives on the treatment of BRAF mutated colorectal carcinoma

Czech version

Authors: MUDr. Batko Stanislav
Authors‘ workplace: Onkologická klinika 2. LF a FN Motol
Published in: Klin Onkol 2020; 33(5): 328-338
Category: Review
doi: https://doi.org/10.14735/amko2020328

Overview

Background: Worldwide metastatic colorectal cancer is the second most common cause of death attributable to cancer. Advances in molecular diagnostics led to recognition of several molecular subtypes of this disease. BRAF mutated colorectal cancer define specific challenging subgroup associated with dismal prognosis, lower rate of response rate, shorter progression free survival and overall survival. Current treatment choices are associated with poor outcomes. For the first line treatment doublet or triplet chemotherapy plus antiangiogenic antibody is used. To date, there were no reasonable treatment options in the second line settings. Recently published BEACON trial sets new standard of treatment with combination of encorafenib plus cetuximab, which led to significantly longer overall survival and overall response compared to standard therapy. Furthermore, this combination has shown well-tolerated safety profile with manageable toxicities.

Purpose: The aim of this article is a review of current treatment options for BRAF mutated colorectal cancer.

Keywords:

metastatic colorectal cancer – cetuximab – BRAF V600E – encorafenib – binimetinib – BEACON

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