#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Vulvar Intraepithelial Neoplasia


Authors: P. Mikloš 1;  P. Babala 1;  M. Klačko 1;  L. Masák 1;  D. Ondruš 2
Authors‘ workplace: Klinika gynekologickej onkológie OÚSA a SZU Bratislava, Slovenská republika 1;  I. onkologická klinika LF UK a OÚSA Bratislava, Slovenská republika 2
Published in: Klin Onkol 2011; 24(1): 50-53
Category: Short Communication

Overview

HPV infections of the lower genital tract are associated with the increasing incidence of vulvar intraepithelial neoplasia. The new classification divides vulvar intraepithelial neoplasia according to its incidence into two groups: usual and differentiated type. The usual type occurs mainly in young women and is associated with HPV infection, the differentiated type is HPV-negative and occurs in older women. The diagnosis is based on biopsy from a suspicious lesion. The standard treatment involves surgical excision. Topical treatment is now being preferred in young women in order to preserve appearance of the genitalia and sexual function. The high risk of recurrence is the reason for strict monitoring of patients after treatment completion.

Key words:
vulva – vulvar intraepithelial neoplasia – cancer – classification – treatment


Sources

1. Safaei-Diba Ch, Pleško I, Obšitníková A et al. Incidencia zhubných nádorov v Slovenskej republike 2005. Národný onkologický register SR. NCZI 2009.

2. Ondrušová M, Pleško I, Safaei-Diba Ch et al. Komplexná analýza výskytu a úmrtnosti na zhubné nádory v Slovenskej republike [online]. Bratislava, Národný onkologický register SR, NCZI, 2007. http://www.nor-sk.org/.

3. Iversen T, Tretli S. Intraepitelial and invasive squamous cell neoplasia of the vulva: trends in incidence, recurrence, and survival rate in Norway. Obstet Gynecol 1998; 91(6): 969–972.

4. Jones RW, Rowan DM. Vulvar intraepitelial neoplasia III: a clinical study of outcome in 113 cases with relation to the later development of invasive vulvar carcinoma. Obstet Gynecol 1994; 84(5): 741–745.

5. Joura EA, Lösch A, Haider-Angeler MG et al. Trends in vulvar neoplasia. Increasing incidence of vulvar intraepitelial neoplasia and squamous cell carcinoma of the vulva in young women. J Reprod Med 2000; 45(8): 613–615.

6. Anastasidis P, Skaphida P, Koutlaki N et al. Trends in epidemiology of preinvasive and invasive vulvar neoplasias. 13 year retrospective analysis in Thrace, Greece. Arch Gynecol Obstet 2000; 264(2): 74–79.

7. Kuhn L, Sun XW, Wright Jr TC. Human immunodefi­ciency virus infection and female lowr genital tract malignancy. Curr Opin Obstet Gynecol 1999; 11: 35–39.

8. Bowen JT. Precancerous dermatoses: a study of two cases of chronic atypical epithelial proliferation. J Cutan Dis Syph 1912; 30: 241–255.

9. Kaufman RH, Gardner HL. Intraepitelial carcinoma of the vulva. Clin Obstet Gynecol 1965; 8(4): 1035–1050.

10. Wilkinson EJ, Kneale BL, Lynch FW. Report of the ISSVD terminology commitee: VIN. J Reprod Med 1986; 31: 973–974.

11. Wilkinson EJ, Teixeira MR. Epithelial tumours, squamous tumours. In: Tavassoli FA, Devilee P (eds). World Health Organization Classification of Tumours Pathology and Genetics of Tumours of the Breast and Female Genital Organs. Lyon, France: IARC Press 2003; 230: 316–320.

12. Sideri M, Jones RW, Wilkinson EJ et al. Squamous vulvar intraepithelial neoplasia. 2004 modified terminology, ISSVD Vulvar Oncology Subcommittee. J Repod Med 2005; 50(11): 807–809.

13. van Beurden M, van der Vange N, de Craen AJ et al. Normal findings in vulvar examination and vulvoscopy. Br J Obstet Gynaecol 1997; 104(3): 320–324.

14. Rychterová R. Morfologické aspekty vulvárních lézí. Prakt gynekol 2004; 6: 31–33.

15. Preti M, Van Seters M, Sideri M et al. Squamous vulvar intraepithelial neoplasia. Clin Obstet Gynecol 2005; 48(4): 845–861.

16. Hart W. Vulvar intraepithelial neoplasia: historical aspects and current status. Int J Gyn Pathol 2001; 20(1): 16–30.

17. Benedet JL, Wilson PS, Matisic J. Epidermal thickness and skin appendage involment in vulvar intraepithelial neoplasia. J Reprod Med 1991; 36(8): 608–612.

18. Jansen GT, Dillaha CJ, Honeycutt WM. Bowenoid conditions of the skin: treatment with topical 5-fluorouracil. South Med J 1967; 60(2): 185–188.

19. Sillman FH, Sedlis A, Boyce JG. A review of lover genital intraepithelial neoplasia and the use of topical 5-fluorouracil. Obstet Gynecol Surv 1985; 40(4): 190–220.

20. Davis G, Wentworth J, Richard J. Self-administered topical 5% imiquimod treatment of vulvar intraepithelial neoplasia. A report of fourth cases. J Reprod Med 2000; 45(8): 619–623.

21. Todd RW, Etherington IJ, Lusley DM. The effect of 5% imiquimod cream on high-grade vulvar intraepithelial neoplasia. Gynecol Oncol 2002; 85(1): 701–705.

22. Martin-Hirsch PL, Whitehurst C, Buckley CH et al. Photodynamic treatment for lower genital tract intraepithelial neoplasia. Lancet 1998; 351(9113): 1403.

23. Hillemanns P, Untch M, Dannecker C at al. Photodynamic therapy of vulvar intraepithelial neoplasia using 5-aminolevulinic acid. Int J Cancer 2000; 85(5): 649–653.

24. Hillemanns P, Wang X, Staehle S et al. Evaluation of different treatment modalities for vulvar intraepithelial neoplasia (VIN): CO(2) laser vaporisation, photodynamic therapy, excision and vulvectomy. Gynecol Oncol 2006; 100: 271–275.

25. van Seters M, van Beurden M, de Craen AJ. Is the assumed natural history of vulvar intraepithelial neoplasia III based on evidence? A systematic review of 3 322 published patients. Gynecol Oncol 2005; 97(2): 645–651.

Labels
Paediatric clinical oncology Surgery Clinical oncology
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#