Comparison of conventional radiography with full body magnetic resonance and analysis of bone metabolism analysis in patients with multiple myeloma
Authors:
P. Puščiznová 1; P. Petrová 2; J. Hrbek 3; M. Heřman 3; T. Pika 1; J. Bačovský 1; J. Minařík 1
Authors‘ workplace:
Hemato-onkologická klinika LF UP a FN Olomouc
1; Oddělení klinické biochemie FN a LF UP Olomouc
2; Radiologická klinika
3
Published in:
Klin. Biochem. Metab., 23 (44), 2015, No. 2, p. 48-52
Overview
Objective:
Comparison of radiodiagnostic methods, conventional radiography (X-ray) and whole-body magnetic resonance (MR-WB), to myeloma bone disease (MBD) and to the levels of selected markers of bone metabolism and bone marrow microenvironment.
Material and Methods:
We examined 32 patients with multiple myeloma at the time of diagnosis. All patients were examined by X-ray and whole-body magnetic resonance. Following parameters of bone marrow microenvironment were assessed: osteocalcin (OC), bone alkaline phosphatase (bALP), parathormone (PTH), carboxy-terminal telopeptide of type-I collagen (ICTP),N -terminal propeptide of procollagen type-I (PINP), insulin-like growth factor-1 (IGF-1), hepatocyte growth factor (HGF), syndecan-1 / CD138 (SYN), vascular endothelial growth factor (VEGF), osteoprotegerin (OPG), osteopontin (OPN), endostatin (ES), macrophage inflammatory protein 1α and 1β (MIP-1α, MIP-1β), interleukin-17 (IL-17), and angiogenin (ANG).
Results:
Magnetic resonance imaging was more useful than radiography for 40.63 % of patients, these two methods were exactly the same in 34 % and in 25.37 % they were very similar. There is a positive correlation between X-ray and ICTP (kk=0.306, p=0.023), PINP (kk=0.274, p=0.039) and OPN (kk=0.331, p=0.013). For other parameters the correlation was not statistically significant.
Conclusion:
X-ray has lower sensitivity in assessing of MBD. Our results recommend imaging with WB-MR. Indicators of bone marrow microenvironment have a potential to improve the understanding of biological processes in MBD. Larger group of patients should be evaluated to assess their real benefits. Three parameters are promising in the assessment of the MBD´s extent - ICTP, PINP and OPN.
Keywords:
multiple myeloma, myeloma bone disease, conventional radiography, magnetic resonance, bone marrow microenvironment.
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Clinical Biochemistry and Metabolism
2015 Issue 2
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