Authors: J. Šemberová 1; A. Manthey 2; Z. Ulčová-Gallová 1; M. Pískatá 1; L. Milichovská 1; Z. Rokyta 1 Authors‘ workplace: Gynekologicko-porodnická klinika LF UK a FN, Plzeň, přednosta doc. MUDr. Z. Rokyta, CSc. 2Medac, Hamburg, Německo 1 Published in: Ceska Gynekol 2004; (3): 210-214 Category:
Objective: Detection of IgA and IgG antibodies against Chlamydia trachomatis in various biologicalmaterials in patients with fertility disorders.Design: Retrospective study.Setting: Department of Gynecology and Obstetrics, Medical Faculty of Charles University andFaculty Hospital, Plzeň.Methods: Antichlamydial antibodies IgA and IgG were detected in 73 patients. Examination ofsera was performed in all 73 women, peritoneal fl uid was examined in 20 patients who underwentdiagnostic laparoscopy, follicular fl uid samples in 22 women from IVF programme and antibodiesin cervical ovulatory mucus were examined in 31 patients of the Division of Immunology of Reproduction. Results were compared with clinical fi ndings and data of personal histories. Blooddonors sera examination were used as a control group.Results: High number of chlamydial antibody positivity was found in follicular fl uid – in IgA (18/22, 82%) and IgG (16/22, 73%) and also in ovulatory cervical mucus in IgA (13/31, 42%). Examinationsof sera did not differ signifi cantly from the control group.Conclusion: High levels of chlamydial antibodies in follicular fl uid samples could display connectionbetween chlamydia infection and infertility, mainly as its organic cause (adhesions, tubalfactor). IgA positivity in cervical ovulatory mucus is caused by local antibody production. Serologicexamination of chlamydial antibodies is one of the most suitable examinations of entry ininfertile patients as well as in pregnant women.
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