The Changes of Concentration of IGF-I and its Binding Proteins in Diabetesand Obesity

Czech version

Authors: M. Kršek; J. Škrha; P. Sucharda; V. Justová; Z. Lacinová
Authors‘ workplace: III. interní klinika 1. LF UK a VFN, Praha
Published in: Čas. Lék. čes. 2003; : 216-219
Category:

Overview

Background.
The system of IGF-I and its binding proteins is a complex system with many physiological functionsincluding metabolic regulations. Present study was aimed to describe changes of its particular components in patientswith type 1 and type 2 diabetic patients and patients with obesity.Methods and Results. We examined 21 patients with obesity, 13 patients with type 2 and 22 with type 1 diabetesin comparison with 16 age matched healthy controls. We performed clinical examination and estimation of serumconcentrations of IGF-I, free-IGF-I, IGFBP-1, -2, -3 and -6, insulin, C-peptide and fasting glucose. Patients withobesity featured by decreased IGF-I (p

Key words:
IGF-I, IGFBP, diabetes mellitus, obesity.

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Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental Hygienist

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Article was published in

Journal of Czech Physicians

2003 Issue 4

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