Urapidil –⁠ an antihypertensive drug with a dual action mechanism

Czech version

Authors: Souček M.; Novák J.
Authors‘ workplace: II. interní klinika LF MU a FN U sv. Anny v Brně
Published in: Kardiol Rev Int Med 2020, 22(2): 69-71

Overview

We provide a comprehensive overview of the mechanisms of actions and indications of urapidil in the treatment of hypertension. The antihypertensive effect of most centrally-acting antihypertensive drugs is mediated by the activation of the central alpha-2 adrenergic receptors and/or imidazol receptors located in the cardiovascular regulatory centres in the medulla oblongata. Urapidil is unique in having both a central agonistic effect on the 5-HT1A receptors (and according to primary studies, also a mild agonistic effect on the central alpha-2 receptors) and a peripheral antagonistic effect on postsynaptic alfa-1 receptors. These unique properties make urapidil a well-tolerated drug in the treatment of patients with resistant hypertension.

Keywords:

hypertension – imidazoline receptors – alpha receptors – urapidil

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