Does sacubitril-valsartan have an antiarrhythmic or a pro-arrhythmic effect in patients with heart failure?

Czech version

Authors: Málek F.
Authors‘ workplace: Kardiovaskulární centrum, Nemocnice Na Homolce, Praha
Published in: Kardiol Rev Int Med 2020, 22(2): 78-81

Overview

Angiotensin receptor and neprilysin inhibitor sacubitril-valsartan has been shown to reduce the risk of cardiovascular mortality and the risk of heart failure hospitalisations compared to the standard treatment with enalapril in the PARADIGM-HF randomised comparative clinical outcome study. The cardiovascular mortality risk reduction was caused in part by the reduction of the risk of sudden cardiac death. The sudden death risk reduction may be caused by the indirect antiarrhythmic effect of sacubitril-valsartan, which is explained by a reverse ventricular remodelling and a decrease in the extent of myocardial fibrosis. Despite these facts, some papers have brought information about the potential pro-arrhythmic effect of sacubitril-valsartan.

Keywords:

heart failure – sacubitril-valsartan – ventricular arrhythmias

Sources

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