PCSK9 inhibitors in clinical practice – update

Czech version

Authors: Blaha V.; Víšek J.
Authors‘ workplace: III. interní gerontometabolická klinika LF UK a FN Hradec Králové
Published in: Kardiol Rev Int Med 2019, 21(3): 163-167

Overview

PCSK9 inhibitors belong to the new and extremely efficient lipid-lowering agents, which significantly not only decrease low-density lipoprotein (LDL) cholesterol and other aterogenic lipids including lipoprotein (a), but also significantly lower cardiovascular mortality and morbidity. These drugs are human monoclonal antibodies which block the activity of proprotein convertase subtilisin/kexin type 9 (PCSK9 inhibitors). Even though the PCSK9 inhibitors were approved for clinical use in the Czech Republic in autumn 2015, their prescription was only enabled on 1 June 2018. Recently, the first data from the therapy by PCSK9 inhibitors in real clinical praxis has been collected and evaluated. The following case reports of patients with hypercholesterolemia from our out-patient clinic for the lipid disorders document our recent experience with the PCSK9 inhibitor therapy.

Keywords:

Cholesterol – metabolism of LDL cholesterol – subtilisin/ kexin type 9 proprotein convertase

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