Amiodarone lung toxicity – ‘amiodarone lung’


Authors: Genzor S.;  Žurková M.;  Sova M.;  Kolek V.
Authors‘ workplace: Klinika plicních nemocí a tuberkulózy LF UP a FN Olomouc
Published in: Kardiol Rev Int Med 2019, 21(3): 142-144

Overview

The lung is very sensitive to the possible toxic effects of various agents – either caused by direct toxicity or immunity-driven. The number of drugs with proven lung toxicity is increasing, therefore prescribing physicians should know the possible side effects affecting the lungs. The article briefly summarises cur­rent knowledge about amiodarone lung toxicity. A case report of a typical example is provided in the second part of the article.

Keywords:

amiodarone – drug-induced lung toxicity


Sources

1. Vašáková M, Polák J, Matěj R. Intersticiální plicní procesy: od etiopatogeneze přes radiologický obraz k histopatologické dia­gnóze. 2. vyd. Praha: Maxdorf Jessenius 2016.

2. Lošťáková V, Kuna M, Kolek V et al. Polékové postižení plic. Klin Farmakol Farm 2018: 32(4): 21–31.

3. Kolek V. Doporučené postupy v pneumologii. 2. vyd. Praha: Maxdorf Jessenius 2016.

4. Rotmensch HH, Liron M, Tupilski M et al. Possible association of pneumonitis with amiodarone ther­apy (letter). Am Heart J 1980; 100(3): 412–413. doi: 10.1016/ 0002-8703(80)90165-9.

5. Dusman RE, Stanton MS, Miles WN et al. Clinical features of amiodarone-induced pulmonary toxicity. Circulation 1990; 82(1): 51–59. doi: 10.1161/ 01.cir.82.1.51.

6. Camus P, Martin WJ 2nd, Rosenow EC 3rd. Amiodarone pulmonary toxicity. Clin Chest Med 2004; 25(1): 65–75. doi: 10.1016/ S0272-5231(03)00144-8.

7. Marchlinski FE, Gansler TS, Waxman HL et al. Amiodarone pulmonary toxicity. Ann Int Med 1982; 97(6): 839–845. doi: 10.7326/ 0003-4819-97-6-839.

8. Gleadhill IC, Wise RA, Shonfeld SA et al. Serial lung function in patients treated with amiodarone: a pros­pective study. Am J Med 1989; 86(1): 4–10. doi: 10.1016/ 0002-9343(89)90221-0.

9. Kojima S, Kojima S, Ueno H et al. Increased density of the liver and amiodarone-associated phospholipidosis. Cardiol Res Pract 2009; 2009: 598940. doi: 10.4061/ 2009/ 598940.

10. Chuang CL, Chern MS, Chang SC. Amiodarone toxicity in a patient with simultaneous involvement of cornea, thyroid gland, and lung. Am J Med Sci 2000; 320(1): 64–68. doi: 10.1097/ 00000441-200007000-00010.

11. Jessurum GA, Crijns HJ. Amiodarone pulmonary toxicity. BMJ 1997; 314: 619–620.

12. Myers JL, Kennedy JI, Plumb VJ. Amiodarone lung: pathologic findings in clinically toxic patients. Hum Pathol 1987; 18(4): 349–354. doi: 10.1016/ s0046-8177(87)80164-8.

13. Martin WJ 2nd, Rosenow EC 3rd. Amiodarone pulmonary toxicity: Recognition and pathogenisis (Part 1). Chest 1988; 93(5): 1067–1075. doi: 10.1378/ chest.93.5.1067.

14. Okayasu K, Takeda Y, Kojima J et al. Amiodarone pulmonary toxicity: a patient with three recurrences of pulmonary toxicity and consideration of the probable risk of relapse. Intern Med 2006; 45(22): 1303–1307. doi: 10.2169/ internalmedicine.45.1800.

15. Greenspon AJ, Kidwell GA, Hurley W et al. Amiodarone-related post-operative adult respiratory distress syndrome. Circulation 1991; 84 (Suppl 5): 407–415.

Labels
Paediatric cardiology Internal medicine Cardiac surgery Cardiology
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