Safety and efficacy of new anticoagulants in real world clinical practice

Authors: Olexa P.
Authors‘ workplace: Gerontologická a geriatrická klinika LF UPJŠ a LVN, Košice
Published in: Kardiol Rev Int Med 2019, 21(2): 96-98


The results of a series of four large randomised clinical studies of dabigatran, rivaroxaban, apixaban and edoxaban vs. warfarin have confirmed a higher efficacy and safety of the innovative treatments compared to warfarin. Their main benefit stems primarily from a dramatic reduction in the incidence of intracranial bleeding, as well as from greater effectiveness in reducing thromboembolism. Real-world data (RWD) represent an additional source of information about the safety and efficacy of each non-vitamin K antagonist oral anticoagulant (NOAC). RWD should be seen as complementary information, adding to the results of randomised studies. With the exception of edoxaban, there is currently sufficient information on the effectiveness and safety of these products from RWD analyses. The objective of this retrospective review analysis is to present the results, unfortunately still little known but important, of the completed RWD safety and efficacy analyses of the NOACs and to highlight their contribution to answering the questions concerning the true efficacy and safety profiles of the individual NOAC molecules in clinical practice.


direct anticoagulants – randomised controlled studies – real word data analyses


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Paediatric cardiology Internal medicine Cardiac surgery Cardiology
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