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Antiatherosclerotic and antiinflammatory activities of SGLT2 inhibitors

Czech version

Authors: Ján Murín
Authors‘ workplace: I. interná klinika LFUK a UNB, Nemocnica Staré Mesto, Bratislava
Published in: AtheroRev 2021; 6(1): 25-29
Category:

Overview

Type 2 diabetes mellitus (T2DM) is a systemic disease with many cardiovascular and renal complications. Treatment of DM should be today with new antidiabetic drugs as SGLT2 inhibitors and GLP-1 RA, as they can reduce mentioned complications. In this article we concentrate on SGLT2 inhibitors and their activities: antiatherosclerotic (blood pressure reduction, reduction of epicardial and visceral fat mass, inhibition of lipogenesis, autophagy activation, support for angiogenesis, mTOR inhibition, mitochondrial function improvements, free oxygen radicals reduction) and antiinflammatory (betahydroxybutyrate production increase which has antiinflammatory and antiremodeling activities, free oxygen radicals reduction, reduction of uricaemia, anti-IL-1β activity, reduction of activation of NLRP3 inflammasome, serum levels reduction of TNF-receptor 1 but also IL-6 and matrix metalloproteinase 7). These mechanisms are thoroughly investigated in last years and they can explain CV and renal benefits of SGLT2 inhibitors in diabetic patients.

Keywords:

antiatherosclerotic activities – antiinflammatory activities – diabetes mellitus – SGLT2 inhibitors – antiinflammatory activities – diabetes mellitus – SGLT2 inhibitors

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