The role of linezolide in the treatment of resistant gram-positive infections

Czech version

Authors: P. Dlouhý ¹; I. Herold ²; M. Kolář ³; J. Beneš ⁴; P. Cetkovský ⁵; T. Doležal ⁶; D. Jahoda ⁷; M. Kouba ⁸; I. Novák ⁹; O. Nyč ¹⁰; J. Pilnáček ¹¹; Z. Ráčil ¹²; T. Sechser ¹³; P. Ševčík ¹⁴; P. Švihovec ¹⁵
Authors‘ workplace: Infekční oddělení Masarykovy nemocnice v Ústí nad Labem ¹; Anesteziologicko-resuscitační oddělení Klaudiánovy nemocnice, Mladá Boleslav ²; Ústav mikrobiologie FNO a LF UP, Olomouc ³; II. infekční klinika 3. LF UK a FN Na Bulovce, Praha ⁴; Ústav hematologie a krevní transfuze, Praha ⁵; Ústav farmakologie 3. LF UK, Praha ⁶; Ortopedická klinika 1. LF UK a FN Motol, Praha ⁷; Ústav hematologie a krevní transfuze, Praha ⁸; 1. interní klinika LF UK a FN Plzeň ⁹; Ústav lékařské mikrobiologie 2. LF UK, Praha ¹⁰; Ortopedicko-úrazové oddělení, Nemocnice Kladno ¹¹; Interní hematoonkologická klinika, LF MU a FN Brno ¹²; Pracoviště klinické farmakologie Centra diabetologie IKEM, Praha ¹³; Anesteziologicko-resuscitační klinika, FN U sv. Anny, Brno ¹⁴; Gynekologicko-porodnická klinika, Všeobecná fakultní nemocnice, Praha ¹⁵
Published in: Anest. intenziv. Med., 16, 2005, č. 6, s. 305-312
Category: Intensive Care Medicine - Original Paper

Overview

Incidence of gram-positive infections caused by bacteria resistant to commonly used antibiotics has been on the increase in the past decades. Resistant strains appeared in the Czech Republic later than in other countries, however their number has been increasing and the use of new antibiotics is becoming necessary. The greatest increase of incidence can be seen in infections caused by methicillin-resistant S. aureus and coagulase-negative staphylococci. Vancomycin-resistant enterococci are usually found in hemato-oncology patients. The curative use of vancomycin is limited due to its narrow therapeutical range, nephrotoxicity and limited penetration into tissues (lung) and CSF. Linezolide is a good option mainly in infections of skin and soft tissues, and it has an evincible advantage over vancomycin in the treatment of nosocomial pneumonia and surgical-site infections. Oral forms are favourable allowing switch therapy and earlier discharge from hospital.

Key words:
resistant bacteria – antibiotics – treatment of nosocomial pneumonia – linezolide – MRSA

Labels

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Article was published in

Anaesthesiology and Intensive Care Medicine

2005 Issue 6