Authors: R. Rokyta, jun.; V. Šrámek; M. Matějovič; P. Hora; I. Novák Authors‘ workplace: Metabolická JIP, 1. interní klinika FN a LF UK Plzeň, přednosta prof. MUDr. K. Opatrný jun., CSc. Published in: Anest. intenziv. Med., , 2002, č. 5, s. 237-240 Category:
Objective: To assess the impact of continuous venovenous hemodiafiltration (CVVHDF) initiation on central hemodynamics, oxygen transport andgastric mucosal energy metabolismDesign: Prospective clinical study.Setting: University Hospital medical intensive care unit.Subjects: Fourteen critically ill patients with acute renal failure.Methods: Gastric mucosal PCO2 (pgmCO2) was measured using gastric tonometry at baseline and then at 1,2,3 and 6 hours after starting CVVHDFand gastric mucosal to arterialPCO2 gradient (PCO2gap) was calculated. Whole body hemodynamics was measured invasively (arterial and pulmonaryarterial catheters).Results: PCO2gap remained stable during the first 6 hrs of CVVHDF treatment. Mean arterial pressure, cardiac output, systemic vascular resistanceand global oxygen consumption remained also unaltered although systemic vascular resistance increased.Conclusions: CVVHDF initiation in hemodynamically stable critically ill patients has minor effects on the whole body hemodynamics withoutinfluencing gastric mucosal energy balance.
Key words: CRRT – acute renal failure – gastric tonometry – monitoring – critically ill
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