The Effect of Continuous Veno-venous Hemofiltration on T lymphocytes and Monocytes Activation in Critically Ill Patients in Sepsis
Authors:
J. Příhodová 4; M. Holub 1; J. Hanzlíková 3; M. Matějovič 2; V. Šrámek 2; I. Novák 2
Authors‘ workplace:
3. klinika infekčních a tropických nemocí 1. LF UK, Praha, přednosta doc. MUDr. A. Lobovská, CSc.
1
Published in:
Anest. intenziv. Med., , 2000, č. 6, s. 267-270
Category:
Overview
Elimination methods can improve the prognosis of critically ill patients in sepsis. With respect to that, higher activation of monocytes duringplasmapheresis could possibly play a role (increase of HLA-DR+ monocytes in peripheral blood). We observed a decrease of T lymphocyte activationin 19 patients after 24 hours of continuous veno-venous hemofiltration – CVVH (p < 0,01). On the third day of CVVH this activation returned to thelevels before initiating of the elimination method. Trend of monocyte activation followed the same course; however, it did not reach statisticalsignificance. The observed changes in the activation direct an attention to possible immunomodulatory effects of this elimination method.
Key words:
CVVH – sepsis – HLA-DR – T cells – monocytes – critically ill
Labels
Anaesthesiology, Resuscitation and Inten Intensive Care MedicineArticle was published in
Anaesthesiology and Intensive Care Medicine
2000 Issue 6
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