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Efficacy and Speed of Pain Relief in Rheumatoid Arthritis When Adding Baricitinib to Methotrexate

17. 2. 2020 Source: Biological Treatment

The phase III clinical trial RA-BEAM conducted in patients with rheumatoid arthritis (RA) inadequately controlled by methotrexate demonstrated the benefit of adding baricitinib or adalimumab compared to placebo in terms of reducing the number of swollen joints. However, baricitinib showed greater pain relief starting from week 1 compared to placebo and from week 2 compared to adalimumab. Thus, the recently published results of an analysis using the data from this study aimed to compare the proportion of patients who achieved certain pain…

Can NOACs 'Compete' with Well-Managed Warfarin Treatment? Retrospective Data from Swedish Registers

The efficacy and safety of new oral anticoagulants (NOACs) in stroke prevention in atrial fibrillation have been proven by numerous studies. The quality of warfarin treatment, assessed by the 'time…

17. 2. 2020 Source: Anticoagulant Treatment

Documented Cardiovascular Benefit of Empagliflozin in New American Diabetes Treatment Guidelines

Two leading overseas medical professional societies, the American Diabetes Association (ADA) and the American Association of Clinical Endocrinologists (AACE), released new recommendations for diabetes...

14. 2. 2020 Source: Diabetes

Does the Risk of Recurrence of Differentiated Thyroid Carcinoma Differ by Gender?

Differentiated thyroid carcinomas (DTC) are typically diagnosed at more advanced stages in men than in women, and mortality from this disease is higher among men than women. However, it was not…

14. 2. 2020 Source: Thyroid Disorders

How trends in sports evolve among hemophiliacs and to what extent they are limited by their disease

Historically, physical activity was generally not recommended for hemophiliacs; however, with evolving treatment options and prophylaxis as the gold standard of care for these patients, sports have…

14. 2. 2020 Source: Quality Life Even with Hemophilia

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Incidence of Glaucoma or Suspected Glaucoma Within the First Year Post-Lensectomy in Children and Treatment Approach to These Patients

The aim of the study conducted by a team of authors from several American universities was to determine the approximate incidence of glaucoma or suspected glaucoma in children under 13 years old…

12. 2. 2020 Source: Glaucoma

Metformin in New European Guidelines for Treating Patients with Diabetes and Cardiovascular Disease

The position of metformin has changed in the guidelines for the treatment of prediabetes and type 2 diabetes in individuals with cardiovascular (CV) disease, issued by the European Society of…

12. 2. 2020 Source: Cardiovascular Continuum

Another Positive Effect of Diosmin −⁠ Influence on Oxidative Stress

Diosmin is an established drug in the therapy of chronic venous insufficiency. It is known to act through several different mechanisms. A study by Polish authors provides evidence of its ability to…

11. 2. 2020 Source: Venous Insufficiency

How to Choose the Ideal Venotonic or Vasoprotective –⁠ Which Properties Are Key?

Medicines and dietary supplements containing flavonoids, often hesperidin or diosmin, are available on the market. What should you consider when choosing these products?

11. 2. 2020 Source: Venous Insufficiency

The Role of Probiotics in the Prevention of Childhood Infections

Although common acute respiratory and gastrointestinal infections are a part of childhood, they pose a significant burden on families and the healthcare and social care system. An unexpected role in…

11. 2. 2020 Source: GI, colic and microbiome

Does Emicizumab Change Routine Clinical Practice?

With the increasing number of patients with hemophilia A being treated with emicizumab, the question arises whether its use in any way changes established clinical practice. A team of American…

11. 2. 2020 Source: Quality Life Even with Hemophilia

Should We Test for Alpha-1-Antitrypsin in All COPD Patients?

Approximately 1–2% of patients with chronic obstructive pulmonary disease (COPD) have an alpha-1-antitrypsin (AAT) deficiency. This is an underdiagnosed genetic disorder that leads to rapid…

10. 2. 2020 Source: Deficiency of Alpha-1-Antitrypsin

Lorlatinib as an Alternative to CNS Radiotherapy in Patients with NSCLC −⁠ Case Studies

Two remarkable case studies from authors at the Netherlands Cancer Institute Antoni van Leeuwenhoek in Amsterdam present patients with advanced NSCLC with metastatic CNS involvement. Treatment with…

10. 2. 2020 Source: Genetic Profile and Treatment of NSCLC

Idarucizumab reverses the anticoagulant effect of dabigatran even in patients with impaired renal function –⁠ clinical practice commentary

Along with the results of a subanalysis of the RE-VERSE AD study, which demonstrated the efficacy of idarucizumab in reversing the anticoagulant effect of dabigatran regardless of the level of renal…

10. 2. 2020 Source: Anticoagulant Treatment

Does The Use of Levothyroxine in Women with Thyroid Peroxidase Antibodies Affect The Risk of Miscarriage and Premature Birth?

Women with thyroid peroxidase antibodies have a higher risk of miscarriage and premature birth, even if they have normal thyroid function. The British study presented below aimed to clarify whether…

10. 2. 2020 Source: Thyroid Disorders

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