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Benefit of Maintenance Therapy with Olaparib in Newly Diagnosed Advanced Ovarian Cancer

17. 3. 2020 Source: Ovarian and Breast Cancer

The SOLO-1 study evaluated whether the use of the PARP inhibitor olaparib in the maintenance treatment of patients with newly diagnosed advanced ovarian, fallopian tube, or peritoneal cancer with BRCA 1/2 mutation leads to an improved prognosis for these patients.

Metamizole in perioperative treatment in children under 14 years –⁠ results of a questionnaire survey from practice

A recent survey among German-speaking physicians evaluated the use of non-opioid analgesics in perioperative care in children under 14 years. It focused on the use of metamizole and the monitoring of…

17. 3. 2020 Source: Analgesia

Spiolto Respimat System –⁠ Innovation for Easier Inhalation

Inhalation delivery is the most preferred method of drug administration in chronic obstructive pulmonary disease and bronchial asthma. The effectiveness of therapy is also conditioned by the correct…

16. 3. 2020 Source: COPD

Prognostic Significance of Subclinical Joint Changes on MRI in Hemophilia

Experience shows that monitoring joint changes, especially subclinical ones, is very necessary in the care of hemophiliacs. Unfortunately, conventional X-rays cannot detect early changes in joints.…

16. 3. 2020 Source: Hemophilia

Safety and Tolerance of Metamizole in Postoperative Analgesia in Children

Due to the potential serious side effects of metamizole, the use of this drug in children is often a topic of discussion. Therefore, a prospective multicenter observational non-interventional…

16. 3. 2020 Source: Analgesia

Type of Pharmacological Thromboprophylaxis and Disease Stage as Risk Factors for Bleeding in Patients After Colorectal Cancer Surgery

Japanese authors of a study published last year in the World Journal of Surgical Oncology attempted to answer the question of whether the incidence of postoperative bleeding in patients undergoing…

14. 3. 2020 Source: Thromboprophylaxis

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European Survey on Prophylactic Treatment of Chemotherapy-Induced Nausea and Vomiting Suggests Gaps in Practice and Ways to Improve

Using recommended guidelines for antiemetic prophylaxis can prevent chemotherapy-induced nausea and vomiting (CINV). Nurses play a significant role in administering prophylactic treatment for CINV.…

13. 3. 2020 Source: Antiemetic Therapy

New drugs in CLL may also carry specific risks of adverse effects. How to minimize and manage them?

The possibilities for the treatment of chronic lymphocytic leukemia (CLL) have greatly expanded in recent years. Significant changes have been brought particularly by small molecule-based therapeutic…

13. 3. 2020 Source: Chronic Lymphocytic Leukemia

Safety and Efficacy of Different Antithrombotic Regimens in Patients with Atrial Fibrillation after Percutaneous Coronary Intervention

Patients with atrial fibrillation (AF) and acute coronary syndrome (ACS) or after percutaneous coronary intervention (PCI) require antithrombotic therapy for the prevention of atherothrombosis, stent…

13. 3. 2020 Source: Anticoagulant Treatment

Treatment of HFrEF with Sacubitril/Valsartan Does Not Have to Be the ‘Last Resort’

The TRANSITION study has provided evidence on the safety and efficacy of administering sacubitril/valsartan to patients after acute decompensation of chronic heart failure with reduced ejection…

9. 3. 2020 Source: Chronic Heart Failure and Lipidology

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Could candesartan counteract adverse intestinal changes induced by hypertension?

An experimental study published last year was the first to show that administration of candesartan may increase the tightness of epithelial junctions in the intestinal wall and positively affect the…

6. 3. 2020 Source: Sartans in the Treatment of Hypertension

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Pharmacokinetics and Safety Profile of Bilastine in Patients Aged 6–11 Years –⁠ Findings from Post-hoc Analysis of Studies

The second-generation antihistamine bilastine is approved in Europe for the treatment of allergic rhinoconjunctivitis and urticaria in children over 6 years old. Post-hoc analyses of two clinical…

4. 3. 2020 Source: Allergic Reactions

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A Brief History of Deep Vein Thrombosis Treatment –⁠ From Antiquity to the Present

Deep vein thrombosis is among the common diseases that have accompanied humanity since its inception. Due to the low specificity of its clinical presentation (in contrast to, for example, varicose…

4. 3. 2020 Source: Prevention of Thrombosis in Surgery

Current Recommendations of the American Society of Hematology for the Prevention of Thromboembolic Disease and Duration of Prophylaxis in Patients Undergoing Major Surgery

At the end of 2019, new recommendations were published by the American Society of Hematology (ASH) for the prevention of thromboembolic disease (VTE) in hospitalized patients. The new guidelines also…

4. 3. 2020 Source: Prevention of Thrombosis in Surgery

More Patients Will Now Have Access to Incontinence Aids

Since December of last year, new rules have been in effect for the prescription of medical aids prescribed through vouchers, including aids for urine collection and voiding. The new rules are…

3. 3. 2020 Source: Incontinence

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