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Diosmin and its application in the treatment of venous insufficiency

27. 3. 2020 Source: Venous Insufficiency

A number of procedures, including pharmacotherapy, are used in the treatment of chronic venous insufficiency, in which diosmin, for example, is applied. The report by pharmacologist MUDr. Jiří Slíva, Ph.D., summarizes the mechanism of action and pharmacological properties of this substance.

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Efficacy and Safety of Gene Therapy Using Adeno-Associated Virus Vector in Patients with Choroideremia

Choroideremia (CHM) is a rare genetically conditioned retinal disease caused by mutations in the CHM gene, leading to a lack of production of the protein REP1 (ras-associated binding escort protein…
27. 3. 2020 Source: Glaucoma
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Results of ATTUNE Total Knee Replacement Implantation –⁠ Data from the National Joint Registry for England, Wales, Northern Ireland and the Isle of Man

The ATTUNE knee replacement system was fully introduced into clinical practice in 2013. Since then, tens of thousands of implants have been administered to patients worldwide. The mid-term results…
26. 3. 2020 Source: Large Joints
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Options of Anticoagulant Therapy During Pregnancy: Focus on Fondaparinux

The use of most medicinal products is limited during pregnancy either by known teratogenic effects or by lack of safety data for the mother and fetus. A systematic review by authors from the…
24. 3. 2020 Source: Management of Thrombosis in Women
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Alternative to benzodiazepines or clomethiazole in the treatment of alcohol withdrawal syndrome?

Alcohol withdrawal syndrome (AWS) is a potentially life-threatening condition. A meta-analysis published in the journal Pharmacopsychiatry in September 2019 examines the effect of the combination of…
20. 3. 2020 Source: Geriatric Patient
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Importance of pH in Care for Stoma Patients

Maintaining good quality peristomal skin and preventing complications related to the stoma site are integral parts of comprehensive care for patients with stomas. The pH of the skin also plays an…
19. 3. 2020 Source: Ostomy

Combination of SGLT2 inhibitors with metformin in terms of mechanism of action

In the treatment of type 2 diabetes (T2D), metformin is recommended as the first-line drug alongside lifestyle modification. However, with disease progression, monotherapy is often insufficient. SGLT2...
18. 3. 2020 Source: Diabetes
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Immunotolerance is still the goal of management of hemophilia A with inhibitor in the era of non-factor therapy

New molecules in hemophilia therapy have raised many questions, including regarding the significance and need for immune tolerance induction (ITI). Interesting conclusions from the FIT (Future of…
18. 3. 2020 Source: Hemophilia
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Basic Information on the Spread and Course of COVID-19 Infection in China: What We Know So Far?

Currently, we are experiencing a worldwide outbreak of COVID-19 infection caused by the SARS-CoV-2 virus, with the first cases identified in December 2019 in Wuhan, China. As of March 18, 2020,…
17. 3. 2020 Source: Anti-Infectives
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Rapid Diagnosis of Depression in Primary Care Settings

Depression is one of the most commonly occurring psychiatric disorders encountered in general practitioners' offices. The general public also very often uses the term “depression” to mean “bad mood.”…
17. 3. 2020 Source: Depression and Anxiety
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The Link Between Various Sleep Disorders and the Onset of Depression: What Findings Did the Population Study in Denmark Bring?

A Danish population study published in June 2019 examined the link between different types of sleep disorders and the risk of developing depression. Which disorders confirmed this link after…
17. 3. 2020 Source: Depression and Anxiety

Insufficient dosing of enoxaparin is common in patients post-orthopedic surgery and increases the risk of thromboembolic disease

Orthopedic and traumatological procedures involving the pelvis and lower limbs are associated with a significant increase in the risk of thromboembolic disease. Therefore, prophylaxis with…
17. 3. 2020 Source: Thromboprophylaxis
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Dabigatran as Effective Prevention of VTE Recurrence Also in Patients with Thrombophilia

With increasing positive experience with direct oral anticoagulants, the question arises of how these drugs work in different groups of patients −⁠ for example, in those who have a congenital or…
17. 3. 2020 Source: Anticoagulant Treatment
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Trazodone as a Multimodal and Multifunctional Antidepressant

Substances with multiple therapeutic effects, often depending on the dose, can be described as multifunctional. In low doses, trazodone has hypnotic effects, while its effective antidepressant action…
17. 3. 2020 Source: Depression and Anxiety
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Prognostic Significance of Lymphopenia for Stratification of Patients with Follicular Lymphoma

The therapy of follicular lymphoma (FL) is guided by several prognostic indices, such as the Follicular Lymphoma International Prognostic Index (FLIPI). The retrospective analysis of 736 patients…
17. 3. 2020 Source: Non-Hodgkin Lymphomas and CLL
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