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News How to Reduce the Risk of Venous Thromboembolism in Users of Combined Hormonal Contraceptives?

The use of combined oral contraceptives (COCs) is a known risk factor for thromboembolism. Therefore, we should consider the individual risk of each patient before prescribing COCs. Women with a positive personal or family history of thromboembolic events should undergo molecular genetic testing for the presence of thrombophilic mutations.

Source: Genetics 27. 6. 2023

News Pain Management After Day Surgery

Effective pain control is a crucial part of recovery for patients after painful surgical procedures. In clinical practice, combined analgesia using paracetamol and nonsteroidal anti-inflammatory drugs (NSAIDs) is commonly utilized, which, however, is not suitable for up to a quarter of patients. An alternative could be metamizole. A study published in the European Journal of Anaesthesiology evaluated the non-inferiority of the combination of paracetamol/metamizole versus paracetamol/ibuprofen in pain management for patients after day surgery.

Source: Analgesia 21. 4. 2022

News Optimization of Enoxaparin Dosing in Obese Patients

Obesity is a risk factor for venous thromboembolism; however, there is uncertainty regarding the optimal dose of enoxaparin for treating acute episodes in the obese population. Two observational studies published last year focused on the efficacy and safety of enoxaparin depending on the dose. The standard dose of 1 mg/kg may be too high for some patients, and fixed dosing without monitoring Xa levels may not be adequate.

Source: Thromboprophylaxis 4. 4. 2022

News Antiglaucoma Eye Drops with Preservatives –⁠ Higher Likelihood of Glaucoma Surgery?

A recently published French study sought to answer the question of whether there is a connection between the presence of preservatives in antiglaucoma eye drops and the probability of undergoing glaucoma surgery.

Source: Treatment of Glaucoma 18. 2. 2021

News Barth Syndrome Has Its First Approved Therapy —⁠ For Now Only in the U.S.

The accelerated approval of elamipretide by the U.S. FDA marks a historic milestone in the treatment of mitochondrial diseases. It is the first therapy targeting cardiolipin dysfunction and the first approved drug for patients with Barth syndrome —⁠ an ultra-rare, life-threatening disorder that primarily affects boys.

Source: 26. 11. 2025

News Relationship between Thyroid Gland Echogenicity and Its Function in Pediatric Patients with Hashimoto's Thyroiditis

Hashimoto's (chronic lymphocytic) thyroiditis is the most common cause of acquired hypothyroidism in both adults and pediatric patients in developed countries. The study presented below explored the relationship between thyroid gland (TG) echogenicity observed in ultrasound (US) examinations and its function in patients diagnosed with this condition.

Source: Thyroid Disorders 22. 9. 2021

News Compression Therapy with Zinc Oxide Dressings in Dermatology

Zinc oxide dressings have a long-standing tradition and continue to find their place in modern dermatology. Compression therapy is the cornerstone of conservative treatment for chronic venous insufficiency and lymphatic insufficiency and should not be overlooked even at the stage of venous leg ulcers.

Source: Wound Healing 10. 5. 2023

News Current European Recommendations for the Treatment of Renal Colic Due to Urolithiasis

At the annual congress in Milan in 2023, new recommendations from the European Association of Urology (EAU) for the acute treatment of patients with renal colic were presented. We summarize the key points concerning primarily analgesic treatment.

Source: Analgesia 21. 6. 2024

News Incontinence as a Consequence of Surgical Procedure on the Prostate

Despite the advent of new surgical methods, urinary incontinence after prostate procedures remains a clinically significant iatrogenic complication. For patients, it represents a significant stress factor that carries physical and psychosocial consequences.

Source: Incontinence 17. 4. 2020

News Positive Effect of Pregabalin Not Only on Neuropathic Pain in Patients with Spinal Cord Injury

Spinal cord injury is often accompanied by painful conditions. A study published in the prestigious journal Neurology demonstrated that administering pregabalin to these patients can bring more than just pain relief.

Source: Neuropathic Pain 18. 2. 2020

Články časopisu Autoimmune Liver Diseases in Children. Part I

Author of the article: P. Dědek Source: Česko-slovenská pediatrie | 12/2010 13. 12. 2010

News Oral Azacitidine Prolongs Survival of AML Patients Regardless of Measurable Residual Disease

Intensive chemotherapy for patients newly diagnosed with acute myeloid leukemia (AML) often achieves high remission rates, although these remissions are often only temporary. Consolidation therapy with azacitidine (AZA) extends post-remission survival and disease-free intervals.

Source: Acute Myeloid Leukemia 6. 6. 2023

News Analgesic Effects of Using Ringer's Solution in Wound Healing Management

Pain resulting from skin defects of various etiologies causes significant discomfort for the patient. However, wound care using Ringer's solution and the use of primary dressings, which include this solution to maintain a constant moist environment in the wound, can help address this problem.

Source: Wound Healing 25. 2. 2022

News Diosmin and Hesperidin: What Does Pharmacokinetics Show?

Flavonoids are plant-derived compounds that have a number of beneficial pharmacological effects. Among the most well-known flavonoids, alongside rutin, are diosmin and hesperidin, which are used as venotonics and vasoprotectives in chronic venous insufficiency (CVI).

Source: Venous Insufficiency 23. 4. 2020

News Odor in Incontinence is a Common Concern of Patients

Urinary incontinence represents a significant stigma, which usually deprives the affected person of all social contact, work and leisure activities, as well as intimate life. According to statistics, fears of odor contribute significantly to this isolation, almost in 40% of cases.

Source: Incontinence 9. 9. 2020