Search

News State of the Intestinal Microbiome and COVID-19 Infection −⁠ Possible Correlations

Some patients infected with the SARS-CoV-2 virus exhibit gastrointestinal symptoms, including diarrhea, during the course of COVID-19. Current knowledge suggests that COVID-19 symptoms are related, among other things, to the intestinal microbiome. Could the use of probiotics therefore act as a prevention of this disease or its more severe course?

Source: GI, colic and microbiome 16. 2. 2021

News Comorbidities of Migraine and Their Impact on Pain Frequency and Intensity

The MAST study, published in March of this year in the prestigious The Journal of Headache and Pain, focused on the occurrence of associated diseases in patients with migraine. What is the prevalence of individual comorbidities and which of them are associated with changes in pain intensity and frequency?

Source: Migraine 27. 7. 2020

News X-ray in Dentistry: Who Can Indicate and Who Can Perform?

X-ray is an integral and important part of dental diagnostics. However, since it is also a source of ionizing radiation, its use is subject to legislative regulations that govern it.

Source: Dental Care 4. 6. 2024

Články časopisu Bone cement implantation syndrome

Author of the article: Filip Čechlovský Source: Úrazová chirurgie | 2/2017 17. 5. 2018

News When to Suspect Dravet Syndrome?

In 2022, an international consensus panel of experts on the diagnosis and treatment of Dravet syndrome was published. This was created due to the recently approved specific treatments for this disease and the development of disease-modifying therapies. The goal of the consensus is to improve diagnosis, set therapeutic goals, and optimal treatment procedures. We summarize the symptoms of the disease and situations in which genetic testing of the causal mutation is appropriate.

Source: Rare Diseases in Neurology 29. 6. 2023

News Initial Treatment for Newly Diagnosed ITP Patients at a Glance

The revised international consensus on the management of primary immune thrombocytopenia (ITP) from 2019 outlines several points summarizing suitable initial treatment for newly diagnosed individuals with ITP.

Source: Immune Thrombocytopenia 21. 2. 2023

News Index of Prostate Health as a Predictive Biomarker of Biopsy Outcome

As demonstrated by Spanish authors in their work published at the beginning of 2018, the Prostate Health Index (PHI) is a biomarker that can refine the prediction of prostate biopsy outcomes in men with elevated prostate-specific antigen (PSA) levels.

Source: Prostate Health Index 2. 4. 2020

News Tapentadol Hydrochloride in Clinical Practice –⁠ To Whom, When, How, and Why?

Thanks to its specific properties, tapentadol hydrochloride ranks among the most effective opioids for managing chronic non-cancer pain. Unlike most opioids, it also exhibits an analgesic effect in neuropathic pain. The following brief overview summarizes its mechanism of action and resulting benefits, reimbursement and prescription conditions, its place in the pain management algorithm, and examples of its application in clinical practice.

Source: Updates in Pain Treatment 12. 10. 2023

News Discontinuation of Methotrexate After Initiation of Tofacitinib in the Treatment of Rheumatoid Arthritis

New real-world data show that in patients with rheumatoid arthritis (RA) who started treatment with tofacitinib combined with oral methotrexate (MTX), it is possible to discontinue MTX and achieve the same treatment results as with its continued use, additionally at lower costs.

Source: Arthritis 27. 7. 2022

News Position of Levodropropizine in Cough Therapy

An international group of specialists focused in 2016–2017 on a detailed evaluation of current options for cough therapy. The authors based their analysis on individually prepared reviews using Medline and Embase databases, and they presented their work's results last year in the journal Pulmonary Pharmacology & Therapeutics.

Source: Cough Therapy 15. 1. 2020

News Deficit dihydropyrimidine dehydrogenase and its association with 5-fluorouracil toxicity

Deficit dihydropyrimidine dehydrogenase (DPD) is a risk factor for severe toxicity of 5-fluorouracil (5-FU). Below, we summarize current knowledge regarding the identification of patients with pathogenic variants of the DPYD gene and study results concerning the safety of therapy with respect to dose individualization based on genotyping.

Source: Genetics 12. 6. 2023

News Non-factor vs. Factor Prophylaxis of Hemophilia A: A Comparison of Cost and Treatment Effectiveness Based on Real-World Data from the USA

In the prophylactic treatment of patients with hemophilia A, particularly its severe form, concentrates of clotting factor VIII (FVIII) with extended half-life (EHL) are increasingly administered, or non-factor treatment, represented in clinical practice by FVIII mimetic antibody emicizumab. However, insights into the direct comparison of effectiveness and economic burden arising from prophylaxis with these modalities are limited, including data from real-world practice. One recently published study therefore attempted to conduct such a retrospective comparison based on data from healthcare-related databases in the USA.

Source: Hemophilia 30. 6. 2023

News How and when does the reaction to gluten begin in coeliac disease? A new Canadian study offers potential answers

As is well known, coeliac disease is a systemic autoimmune disorder characterised by damage to intestinal epithelial cells (IEC). Canadian researchers have sought to uncover the relationship between intestinal epithelial cells and T lymphocyte activation in this disease. The results of their work provide hope for the potential development of an effective therapy.

Source: 6. 11. 2024

News Effect of Short-Term and Long-Term Stress on Heart Rate Variability

Acute and chronic stress significantly affects the cardiovascular (CV) system. The study presented below examines the effects of both acute and chronic stress on heart rate variability in 50 healthy individuals.

Source: Cardiovascular Continuum 13. 4. 2021

Články časopisu Menstrual migraine (migraine without aura): diagnostic and possibility of hormonal treatment

Author of the article: Ingrid Niedermayerová Source: Praktická gynekologie | 1/2012 22. 1. 2012