The use of plasma rich in thrombocytes in the wound healing – some new information and the first experience
Authors:
Igor Slaninka 1,2; Leo Klein 1,2,3; František Hošek 1,2; Lucie Hasenöhrlová 1,2; Stanislav Jíška 1,2; Milan Kaška 1,2
Authors‘ workplace:
Katedra chirurgie, LF UK, Hradec Králové
1; Chirurgická klinika, LF UK a FN Hradec Králové
2; Katedra válečné chirurgie, Fakulta vojenského zdravotnictví UO, Hradec Králové
3
Published in:
Hojení ran 7, č. 2: 25-27, 2013
Category:
Overview
Despite significant advances in the treatment of wounds during the decades there are still wounds that we are fail to heal despite all efforts. The authors present the current knowledge of wound healing with the use of platelet rich plasma (PRP) as a source of growth factors. Delivery of growth factors can accelerate the healing process or prevent the transition of acute wounds to chronicity. Mostly risk groups of patients can profit from that as well as the patients with chronic wound who have failed conventional methods available to general and local therapy. This fact is confirmed by the authors group first experiences.
Key words:
platelet-rich plasma, platelets, wound healing, growing factors
Sources
Abate, M., Di Gregorio, P., Schiavone, C. et al. Platelet rich plasma in tendinopathies: how to explain the failure. Int J Immunopathol Pharmacol 25, 2: 325–234, 2012.
Anitua, E., Andia, I., Ardanza, B. et al. Autologous platelets as a source of proteins for healing and tissue regeneration. Thromb Haemost 91, 1: 4–15, 2004.
Bhanot, S., Alex, J. C. Current applications of platelet gels in facial plastic surgery. Facial Plast Surg 18, 1: 27–33, 2002.
Borregaard, N., Cowland, J. B. Granules of the human neutrophilic polymorphonuclear leukocyte. Blood 89, 10: 3503–3521, 1997.
Casati, M. Z., de Vasconcelos Gurgel, B. C., Gonçalves, P. F. et al. Platelet-rich plasma does not improve bone regeneration around peri-implant bone defects-a pilot study in dogs. Int J Oral Maxillofac Surg 36, 2: 132–136, 2007.
Cole, B. J., Seroyer, S. T., Filardo, G. et al. Platelet-rich plasma: where are we now and where are we going? Sports Health 2, 3: 203–210, 2010.
Dionyssiou, D., Demiri, E., Foroglou, P. et al. The effectiveness of intralesional injection of platelet-rich plasma in accelerating the healing of chronic ulcers. An experimental and clinical study. Int Wound J doi:10.1111: 1742–1748, 2012.
Driver, V. R., Hanft, J., Fylling, C. P., Beriou, J. M.; Autologel Diabetic Foot Ulcer Study Group. A prospective, randomized, controlled trial of autologous platelet-rich plasma gel for the treatment of diabetic foot ulcers. Ostomy Wound Manage 52, 6: 68–70, 2006.
Frechette, J. P., Martineau, I., Gagnon, G. Plateletrich plasmas: growth factor content and roles inwound healing. J Dent Res 84, 5: 434–439, 2005.
Graziani, F., Ivanovski, S., Cei, S. et al. The in vitro effect of different PRP concentrations on osteoblasts and fibroblasts. Clin Oral Implants Res 17, 2: 212–219, 2006.
Lindeboom, J. A., Mathura, K. R., Aartman, I. H. et al. Influence of the application of platelet-enriched plasma in oral mucosal wound healing. Clin Oral Implants Res 18, 1: 133–139, 2007.
Nachman, R. L., Rafii, S. Platelets, petechiae, and preservation of the vascular wall. The N Engl J Med 359, 12: 1261–1270, 2008.
Pietrzak,W. S., Eppley, B. L. Platelet rich plasma: biology and new technology. J Craniofac Surg 16, 6: 1043–1054, 2005.
Qureshi, A. H., Chaoji, V., Maiguel, D. Proteomic and phospho-proteomic profile of human platelets in basal, resting state: insights into integrin signaling. PLoS One 4, 10: e7627, 2009.
Rendu, F., Brohard-Bohn, B. The platelet release reaction: granules’ constituents, secretion and functions. Platelets 12, 5: 261–273, 2001.
Sakata, J., Sasaki, S., Handa, K. A retrospective, longitudinal study to evaluate healing lower extremity wounds in patients with diabetes mellitus and ischemia using standard protocols of care and platelet-rich plasma gel in a Japanese wound care program. Ostomy Wound Manage 58, 4: 36–49, 2012.
Sánchez-González, D. J., Méndez-Bolaina, E., Trejo-Bahena, N. I. Platelet-rich plasma peptides: key for regeneration. Int J Pept 2012: 532519, 2012.
Shengyun, H., Zuolin, W. Platelet-rich plasma-derived growth factors promotes osteogenic differentiation of rat muscle satellite cells: in vitro and in vivo studies. Cell Biol Int 36, 12: 1195–1205, 2012.
Stryja, J. Použití fibrinu bohatého na krevní destičky v rámci komplexní terapie bércového vředu – kazuistika. Hojení ran 6, 3:17–21, 2012.
Wrotniak, M., Bielecki, T., Gazdzik, T. S. Current opinion about using the platelet-rich gel in orthopaedics and trauma surgery. Ortop Traumatol Rehabil 9, 3: 227–238, 2007.
Wysocki, A. B. Evaluating and managing open skin wounds: colonization versus infection. AACN Clin Issues 13, 3: 382–397, 2002.
Labels
Surgery Nurse Home nurseArticle was published in
Wound Healing
2013 Issue 2
Most read in this issue
- The complex regional pain syndrome in a wound treatment
- The importance of antimicrobial prophylaxis on urgent appendectomy
- Cellulose materials in the wound healing
- Perinatal traumatism