KIDNEY CANCER: NEW CONCEPTS IN EVALUATION AND MANAGEMENT
Authors:
M. L. Blute; P. R. Russo; R. Bukowski
Authors‘ workplace:
Cancer Center of Excellence University of Massachusetts Medical School
Published in:
Urol List 2010; 8(2): 6-10
Overview
Renal cancer effects more than 57,000 Americans each year and it is estimated that more than 13,000 will die of this disease in the U. S. this year. The rate of increase in incidence is 2.5 % a year and kidney cancer is now one of the top 10 malignancies in U. S. according to the American Cancer Society. This rate of increase is unlike any other GU malignancy. We now know that there is a number of different subtypes each associated with a specific genetic defect that accounts for the phenotype of each. No GU malig nancy has undergone as significant change in approach to localized or metatstatic disease in the last decade. New concepts in understanding the impact of partial vs radical nephrectomy in management of small renal masses in terms of cancer control and preservation of long-term renal function has resulted in paradigm shift away from radical nephrectomy to nephron sparing surgery. Understanding the genetic basis of kidney cancer has lead to development of targeted therapies for patients with advanced kidney cancer. Integrating these novel drugs in the management of advanced kidney cancer has initiated trials in the neoadjuvant and adjuvant setting. How cytoreductive surgery and metastasectomy are sequenced with targeted therapy is now an intensive area of clinical research.
Key words:
kidney cancer, small renal masses, cytoreductive nephrectomy, targeted therapy
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Urological Journal
2010 Issue 2
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