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Recommendations of the Czech Society of Haematology for the diagnosis and treatment of immune thrombocytopenia in adults


Authors: T. Kozák 1;  J. Čermák 2;  O. Černá 1;  L. Červinek 3;  J. Gumulec 4;  A. Hluší 5;  E. Konířová 6;  M. Košťál 7;  J. Maaloufová 2;  D. Pospíšilová 8;  P. Smíšek 9
Authors‘ workplace: Hematologická klinika FN Královské Vinohrady, Praha 1;  Ústav hematologie a krevní transfuze, Praha 2;  Hematologická a onkologická klinika LF MU a FN Brno 3;  Klinika hematoonkologie, LF OU a FN Ostrava 4;  Hemato-onkologická klinika LF UP a FN Olomouc 5;  1. interní klinika – klinika hematologie 1. LF UK a VFN v Praze 6;  IV. interní hematologická klinika LF UK a FN Hradec Králové 7;  Dětská klinika LF UP a FN Olomouc 8;  Klinika dětské hematologie a onkologie 2. LF UK a FN Motol 9
Published in: Transfuze Hematol. dnes,29, 2023, No. 1, p. 68-77.
Category:
doi: https://doi.org/10.48095/cctahd202368

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za Skupinu pro imunitní cytopenie


Sources

1. Rodeghiero F, Stasi R, Gernsheimer T, et al. Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group. Blood. 2009; 113 (11): 2386–2393.

2. Chang JC. TTP-like syndrome: novel concept and molecular pathogenesis of endotheliopathy-associated vascular microthrombotic disease. Thromb J. 2018; 16: 20.

3. Tsai HM, Lian EC. Antibodies to von Willebrand factor-cleaving protease in acute thrombotic thrombocytopenic purpura. N Engl J Med. 1998; 339 (22): 1585–1594.

4. Furlan M, Robles R, Solenthaler M, Wassmer M, Sandoz P, Lammle B. Deficient activity of von Willebrand factor-cleaving protease in chronic relapsing thrombotic thrombocytopenic purpura. Blood. 1997; 89 (9): 3097–3103.

5. Levy GG, Nichols WC, Lian EC, et al. Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura. Nature. 2001; 413 (6855): 488–494.

6. Scully M, Cataland S, Coppo P, et al. Consensus on the standardization of terminology in thrombotic thrombocytopenic purpura and related thrombotic microangiopathies. J Thromb Haemost. 2017; 15 (2): 312–322.

7. Furlan M, Robles R, Lammle B. Partial purification and characterization of a protease from human plasma cleaving von Willebrand factor to fragments produced by in vivo proteolysis. Blood. 1996; 87 (10): 4223–4234.

8. Furlan M, Robles R, Galbusera M, et al. von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome. N Engl J Med. 1998; 339 (22): 1578–1584.

9. Bendapudi PK, Hurwitz S, Fry A, et al. Derivation and external validation of the PLASMIC score for rapid assessment of adults with thrombotic microangiopathies: a cohort study. Lancet Haematol. 2017; 4 (4): e157–e164.

10. Upadhyay VA, Geisler BP, Sun L, et al. Utilizing a PLASMIC score-based approach in the management of suspected immune thrombotic thrombocytopenic purpura: a cost minimization analysis within the Harvard TMA Research Collaborative. Br J Haematol. 2019; 186 (3): 490–498.

11. Coppo P, Schwarzinger M, Buffet M, et al. Predictive features of severe acquired ADAMTS13 deficiency in idiopathic thrombotic microangiopathies: the French TMA reference center experience. PLoS One. 2010; 5 (4): e10208.

12. Zheng XL, Vesely SK, Cataland SR, et al. ISTH guidelines for treatment of thrombotic thrombocytopenic purpura. J Thromb Haemost. 2020; 18 (10): 2496–2502.

13. Takahashi T. Direct antiglobulin test-negative autoimmune hemolytic anemia. Acta Haematol. 2018; 140 (1): 18–19.

14. Vrbensky JR, Moore JE, Arnold DM, Smith JW, Kelton JG, Nazy I. The sensitivity and specificity of platelet autoantibody testing in immune thrombocytopenia: a systematic review and meta-analysis of a dia­gnostic test. J Thromb Haemost. 2019; 17 (5): 787–794.

15. Peng J, Ma SH, Liu J, et al. Association of autoantibody specificity and response to intravenous immunoglobulin G therapy in immune thrombocytopenia: a multicenter cohort study. J Thromb Haemost. 2014; 12 (4): 497–504.

16. Provan D, Arnold DM, Bussel JB, et al. Updated international consensus report on the investigation and management of primary immune thrombocytopenia. Blood Adv. 2019; 3 (22): 3780–817.

17. Palau J, Sancho E, Herrera M, et al. Characteristics and management of primary and other immune thrombocytopenias: Spanish registry study. Hematology. 2017; 22 (8): 484–492.

18. Bradbury CA, Pell J, Hill Q, et al. Mycophenolate mofetil for first-line treatment of immune thrombocytopenia. New Engl J Med. 2021; 385 (10): 885–895.

19. Godeau B, Lesage S, Divine M, Wirquin V, Farcet JP, Bierling P. Treatment of adult chronic autoimmune thrombocytopenic purpura with repeated high-dose intravenous immunoglobulin. Blood. 1993; 82 (5): 1415–1421.

20. Neunert C, Terrell DR, Arnold DM, et al. American Society of Hematology 2019 guidelines for immune thrombocytopenia. Blood Adv. 2019; 3 (23): 3829–3866.

21. Deshayes S, Khellaf M, Zarour A, et al. Long-term safety and efficacy of rituximab in 248 adults with immune thrombocytopenia: Results at 5 years from the French prospective registry ITP-ritux. Am J Hematol. 2019; 94 (12): 1314–1324.

22. Grainger JD, Kuhne T, Hippenmeyer J, Cooper N. Romiplostim in children with newly dia­gnosed or persistent primary immune thrombocytopenia. Ann Hematol. 2021; 100 (9): 2143–2154.

23. Cervinek L, Mayer J, Doubek M. Sustained remission of chronic immune thrombocytopenia after discontinuation of treatment with thrombopoietin-receptor agonists in adults. Int J Hematol. 2015; 102 (1): 7–11.

24. Bussel JB, Cheng G, Saleh MN, et al. Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura. New Engl J Med. 2007; 357 (22): 2237–2247.

25. Kuter DJ, Bussel JB, Lyons RM, et al. Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura: a double-blind randomised controlled trial. Lancet. 2008; 371 (9610): 395–403.

26. Jurczak W, Chojnowski K, Mayer J, et al. Phase 3 randomised study of avatrombopag, a novel thrombopoietin receptor agonist for the treatment of chronic immune thrombocytopenia. Br J Haematol. 2018; 183 (3): 479–490.

27. Ghanima W, Khelif A, Waage A, et al. Rituximab as second-line treatment for adult immune thrombocytopenia (the RITP trial): a multicentre, randomised, double-blind, placebo-controlled trial. Lancet. 2015; 385 (9978): 1653–1661.

28. Miltiadous O, Hou M, Bussel JB. Identifying and treating refractory ITP: difficulty in dia­gnosis and role of combination treatment. Blood. 2020; 135 (7): 472–490.

29. Bussel J, Arnold DM, Grossbard E, et al. Fostamatinib for the treatment of adult persistent and chronic immune thrombocytopenia: Results of two phase 3, randomized, placebo-controlled trials. Am J Hematol. 2018; 93 (7): 921–930.

30. Kappers-Klunne MC, van‘t Veer MB. Cyclosporin A for the treatment of patients with chronic idiopathic thrombocytopenic purpura refractory to corticosteroids or splenectomy. Br J Haematol. 2001; 114 (1): 121–125.

31. Reiner A, Gernsheimer T, Slichter SJ. Pulse cyclophosphamide therapy for refractory autoimmune thrombocytopenic purpura. Blood. 1995; 85 (2): 351–358.

32. Maloisel F, Andres E, Zimmer J, et al. Danazol therapy in patients with chronic idiopathic thrombocytopenic purpura: long-term results. Am J Med. 2004; 116 (9): 590–594.

33. Howard J, Hoffbrand AV, Prentice HG, Mehta A. Mycophenolate mofetil for the treatment of refractory auto-immune haemolytic anaemia and auto-immune thrombocytopenia purpura. Br J Haematol. 2002; 117 (3): 712–715.

34. Al-Samkari H, Kuter DJ. Immune thrombocytopenia in adults: modern approaches to dia­g­­nosis and treatment. Sem Thromb Hemost. 2020; 46 (3): 275–288.

35. Zoghlami-Rintelen C, Weltermann A, Bittermann C, et al. Efficacy and safety of splenectomy in adult chronic immune thrombocytopenia. Ann Hematol. 2003; 82 (5): 290–294.

36. Mageau A, Terriou L, Ebbo M, et al. Splenectomy for primary immune thrombocytopenia revisited in the era of thrombopoietin receptor agonists: New insights for an old treatment. Am J Hematol. 2022; 97 (1): 10–17.

37. Khellaf M, Michel M, Schaeffer A, Bierling P, Godeau B. Assessment of a therapeutic strategy for adults with severe autoimmune thrombocytopenic purpura based on a bleeding score rather than platelet count. Haematologica. 2005; 90 (6): 829–832.

38. Mithoowani S, Gregory-Miller K, Goy J, et al. High-dose dexamethasone compared with prednisone for previously untreated primary immune thrombocytopenia: a systematic review and meta-analysis. Lancet Haematol. 2016; 3 (10): e489–e496.

39. Kovaleva L, Apte S, Damodar S, et al. Safety and efficacy of a 10% intravenous immunoglobulin preparation in patients with immune thrombocytopenic purpura: results of two international, multicenter studies. Immunotherapy. 2016; 8 (12): 1371–1381.

40. Zhou Z, Qiao Z, Li H, et al. Different dosages of intravenous immunoglobulin (IVIg) in treating immune thrombocytopenia with long-term follow-up of three years: Results of a prospective study including 167 cases. Autoimmunity. 2016; 49 (1): 50–57.

41. Spahr JE, Rodgers GM. Treatment of immune-mediated thrombocytopenia purpura with concurrent intravenous immunoglobulin and platelet transfusion: a retrospective review of 40 patients. American journal of hematology. 2008; 83 (2): 122–125.

42. Reese JA, Peck JD, Deschamps DR, et al. Platelet counts during pregnancy. New Engl J Med. 2018; 379 (1): 32–43.

43. Chakravarty EF, Murray ER, Kelman A, Farmer P. Pregnancy outcomes after maternal exposure to rituximab. Blood. 2011; 117 (5): 1499–1506.

44. Cines DB, Levine LD. Thrombocytopenia in pregnancy. Blood. 2017; 130 (21): 2271–2277.

45. Gotestam Skorpen C, Hoeltzenbein M, Tincani A, et al. The EULAR points to consider for use of antirheumatic drugs before pregnancy, and during pregnancy and lactation. Ann Rheum Dis. 2016; 75 (5): 795–810.

46. Chaturvedi S, Arnold DM, McCrae KR. Splenectomy for immune thrombocytopenia: down but not out. Blood. 2018; 131 (11): 1172–1182.

47. Gernsheimer T, James AH, Stasi R. How I treat thrombocytopenia in pregnancy. Blood. 2013; 121 (1): 38–47.

48. Cines DB, Levine LD. Thrombocytopenia in pregnancy. Hematology Am Soc Hematol Educ Program. 2017; 2017 (1): 144–151.

49. Matzdorff A, Meyer O, Ostermann H, et al. Immune thrombocytopenia – current dia­gnostics and therapy: recommendations of a Joint Working Group of DGHO, OGHO, SGH, GPOH, and DGTI. Oncol Res Treat. 2018; 41 (Suppl 5): 1–30.

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