An update on circulating tumor DNA in patients with Hodgkin lymphoma
Authors:
A. Kredátusová; V. Procházka; T. Papajík
Authors‘ workplace:
Hemato-onkologická klinika LF UP a FN Olomouc
Published in:
Transfuze Hematol. dnes,28, 2022, No. 3, p. 135-142.
Category:
Review/Educational Papers
doi:
https://doi.org/10.48095/cctahd2022prolekare.cz9
Overview
Circulating tumour DNA (ctDNA) is a type of extracellular circulating cell-free DNA (ccfDNA, cfDNA) released into the blood of cancer patients by apoptosis and necrosis of tumour cells. It represents an alternative biomarker for the qualitative and quantitative analysis that may together with PET/CT imaging refine the assessment of treatment response in patients with Hodgkin lymphoma. As a dynamic parameter, it could be applied for refining diagnosis, initial screening for mutations and patient risk stratification. During treatment and at its the end, it could be used to evaluate treatment efficacy and may also be useful for further monitoring and relapse prediction.
Keywords:
Hodgkin lymphoma – Circulating tumor DNA – liquid biopsy – minimal residual disease
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Labels
Haematology Internal medicine Clinical oncologyArticle was published in
Transfusion and Haematology Today
2022 Issue 3
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