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AL amyloidosis in pictures
Authors: P. Látalová 1; T. Pika 2; P. Flodr 1
Authors‘ workplace: Ústav klinické a molekulární patologie LF UP v Olomouci 1; Hemato-onkologická klinika FN Olomouc a LF UP v Olomouci 2
Published in: Transfuze Hematol. dnes,20, 2014, No. 3, p. 76-80.
Category: Comprehensive Reports, Original Papers, Case Reports
Overview
Patients with systemic AL amyloidosis are often diagnosed in advanced stages of the disease, although possibilities for detecting this disease and stratifying patients are still expanding and are not restricted only to specialized medical centres. This case report aims to draw attention to the topic from an unusual angle, namely that of the pathologist, supported by photo documentation. It details the case of a patient with greatly advanced disease, which was diagnosed only shortly before death in the stage of highly significant end-organ changes, three months following the first examination by a physician.
Key words:
AL amyloidosis, free light immunoglobulin chains, renal involvement, cardiac involvement
Sources
1. Bird J, Cavenagh J, Hawkins P, et al. Guidelines on the diagnosis and management of AL amyloidosis. Brit J Haematol 2004; 125 : 681-700.
2. Merlini G, Wechalekar AD, Palladini G. Systemic light chain amyloidosis: an update for treating physicians. Blood 2013; 121 : 5124-5130.
3. Gertz MA. Immunoglobulin light chain amyloidosis: 2013 update on diagnosis, prognosis, and treatment. Am J Hematol 2013; 88(5): 416-425.
4. Pika T, Lochman P, Flodr P, et al. Význam stanovení vybraných laboratorních parametrů v diagnostice, stratifikaci a sledování nemocných s AL amyloidózou. Klin Biochem Metab 2013; 21(42): 79-82.
5. Fikrle M, Paleček T, Kuchynka P, et al. Cardiac amyloidosis: A comprehensive review. Cor Vasa 2013; 55: E60-E75.
6. Ščudla V, Pika T. Současné možnosti diagnostiky a léčby systémové AL-amyloidózy. Vnitř Lék 2009; 55 : 77-87.
Labels
Haematology Internal medicine Clinical oncology
Article was published inTransfusion and Haematology Today
2014 Issue 3-
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