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Mechanisms of immune tolerance induction of tumour cells in chronic lymphocytic leukaemia and possibilityof their detection using flow cytometry


Authors: M. Novák;  V. Procházka
Authors‘ workplace: Hematoonkologická klinika, Fakultní nemocnice / Lékařská fakulta UP Olomouc
Published in: Transfuze Hematol. dnes,20, 2014, No. 2, p. 75-82.
Category: Comprehensive Reports, Original Papers, Case Reports

Overview

Tumour immune tolerance or, possibly, alteration of immunity as a whole, is a frequent consequence of tumour cell interaction with cells of the immune system. The main mechanisms of immune tolerance induction include inducing a state of exhaustion in effector CD8+ T cells through interaction of the programmed cell death 1 receptor with its ligands, lower expression of MHC class II proteins on antigen presenting cells to CD4+ T cells, changes in the T regulatory cell pool, impact on tumour microenvironment and anti-apoptotic processes. The effect of therapeutic monoclonal antibodies on immune response by blockage of the programmed cell death pathway is currently the subject of clinical studies.

Key words:
immune tolerance, chronic lymphocytic leukaemia, T- regulatory lymphocytes, blockage programmed cell deathpathway, flow cytometry


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Haematology Internal medicine Clinical oncology

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