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Platelet tests – concise overview


Authors: I. Varga
Authors‘ workplace: Kardiologická klinika, Národný ústav srdcových a cievnych chorôb, a. s., Bratislava
Published in: Transfuze Hematol. dnes,13, 2007, No. 4, p. 184-191.
Category: Comprehensive Reports, Original Papers, Case Reports

Overview

Platelets are an important part of circulation and hemostasis. They preserve vascular integrity by adhesion, shape change, aggregation, release reaction and procoagulant activities. Their hypofunction results in bleeding disorders, hyperfunction conversely to especially arterial thrombosis susceptibility. Current evaluating methods of platelet function represent wide scale of well sophisticated techniques. None of them alone can unfortunately completely inform about platelet function in actual patient. Therefore, there is a need to formulate a standard universal evaluating algorithm for the use of platelet function tests. In addition, this necessity has been highlighted today by so-called resistance to antiplatelet agents.

Key words:
platelets, evaluating methods, bleeding disorders, arterial thrombosis, resistance to antiplatelet agents


Sources

1. Kamath S, Blann AD, Lip GY. Platelet activation: assessment and quantification. Eur Heart 2001; 22:1561-1571.

2. Hrachovinová I, Malý M. Patofyziologie arteriální trombózy. In: Vojáček J, Malý M, et al. Arteriální a žilní trombóza v klinické praxi. 1. vyd. Praha, Grada Publishing 2004; 69–78.

3. Packham MA, Rand ML, Kinlough-Ratbone RL. Aggregation. In: Gresele P, Page C, Fuster V, Vermylen J. Platelets in thrombotic and non-thrombotic disorders. First edition. Cambridge, Cambridge University Press, 2002; 338–356.

4. Gear AR, Polanowska-Grabowska RK. The platelet shape change. In: Gresele P, Page C, Fuster V, Vermylen J. Platelets in thrombotic and non-thrombotic disorders. First edition. Cambridge, Cambridge University Press, 2002; 319–327.

5. Kvasnička J. Trombofilie a trombotické stavy v klinické praxi. 1. vyd. Praha, Grada Publishing, 2003; 299 strán.

6. Salaj P. Laboratorní hodnotení funkce krevných destiček. In: Vojáček J, Malý M, et al. Arteriální a žilní trombóza v klinické praxi. 1. vyd. Praha, Grada Publishing, 2004; 191–196.

7. Thiagarajan P, Wu KK. In vitro assays for evaluating platelet function. In: Gresele P, Page C, Fuster V, Vermylen J. Platelets in thrombotic and non-thrombotic disorders. First edition. Cambridge, Cambridge University Press, 2002; 459–470.

8. Michelson AD. Platelet function testing in cardiovascular diseases. Circulation 2004; 110: 489–493.

9. Vojáček J, Malý M. Funkce krevných destiček. In: Vojáček J, Malý M, et al. Arteriální a žilní trombóza v klinické praxi. 1. vyd. Praha, Grada Publishing, 2004; 51–68.

10. http://www.labtestonline.org/understanding/analytes/platelet_fun

ction/glance.html. 31.3.2007.

11. Fricke W, Kouides P, Kessler C, et al. A multicenter clinical evaluation of the Clot Signature Analyser. J Thromb Haemost 2004; 2: 763–768.

12. Johns CS. Platelet function testing. Clinical Hemostasis Review 2004; 18: 1–9.

13. Meško D, Pullmann R, Nosáľová G, et al. Vademékum klinickej biochémie. 1. vyd. Martin, Osveta, 1998; 1647 strán.

14. Smith JW, Steinhubl SR, Lincoff AM, et al. Rapid platelet function assay. An automated and quantitative cartridge-based method. Circulation 1999; 99: 620–625.

15. Osende J, Fuster V, Lev EI, et. al. Testing platelet activation with a shear-dependent platelet function test versus aggregation-based tests. Circulation 2001; 103: 1488–1491.

16. Galajda P, Mokáň M. Poruchy hemostázy pri diabetes mellitus. 1. vyd. Martin, PROKONZULT, 2001; 255 strán.

17. Kubisz P, et al. Hematológia a transfuziológia. 1. vyd. Bratislava, Praha, Grada Publishing, 2006; 323 strán.

18. Hankey JH, Eikelboom JW. Aspirin resistance. BMJ 2004; 328: 477–479.

19. Wiviott SD, Antmann EM. Clopidogrel resistance. New chapter in fast-moving story. Circulation 2004; 109: 3064–3067.

20. Patrono C, Coller B, FitzGerald GA, et al. Platelet-Active drugs: The relationships among dose, effectiveness, and side effects. The seventh ACCP conference on antithrombotic and thrombolytic therapy. Chest 2004; 126: 234S–264S.

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Haematology Internal medicine Clinical oncology
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