Idiopathic thrombocytopenic purpura in pregnancy refractory to immunosuppressive treatment – case report
Authors:
J. Procházková 1; M. Procházka 2; T. Papajík 1; E. Látalová 2; A. Hluší 1; M. Lubušký 2; Č. Neoral 3; M. Geierová 4; K. Indrák 1
Authors‘ workplace:
Hemato-onkologická klinika FN a LF UP Olomouc
1; Porodnicko-gynekologická klinika FN a LF UP Olomouc
2; I. chirurgická klinika FN a LF UP Olomouc
3; Ústav patologické anatomie FN a LF UP Olomouc
4
Published in:
Transfuze Hematol. dnes,12, 2006, No. 2, p. 100-103.
Category:
Comprehensive Reports, Original Papers, Case Reports
Overview
Idiopathic thrombocytopenic purpura (ITP) represents an autoimunne disorder complicated by isolated, variably severe thrombocytopenia. The incidence of this condition in pregnancy is 1–2 cases / 1000 uncomplicated deliveries. The main therapeutic approaches in pregnancy include corticosteroids, intravenous imunoglobulins (IVIG) and splenectomy. We present a case of ITP in 27 year-old female during her second pregnancy. The illness was resistant to therapy with corticosteroids (prednisolone 1 mg/kg) as well as to the combination treatment with cyclosporine A. High doses of IVIG led to a few days response only. Due to this poor response we decided to perform splenectomy at the beginning of the 3rd trimester. The surgery and subsequently childbirth of a healthy newborn passed uneventfully.
Key words:
ITP, pregnancy, splenectomy
Labels
Haematology Internal medicine Clinical oncologyArticle was published in
Transfusion and Haematology Today
2006 Issue 2
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