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Diagnosis and Treatment of Childhood Mature B-acute Lymphoblastic Leukaemia inthe Czech Republic in 1990 –2000


Authors: J. Starý 1;  P. Gajdoš 2;  O. Hrušák 3;  D. Pospíšilová 4;  J. Hak 5;  L. Kopečná 6;  K. Michalová 7
Authors‘ workplace: II. dětská klinika UK 2. LF a FN Motol, Praha, 2 Státní zdravotní ústav, Praha, 3 Imunologický ústav UK 2. LF a FN Motol, Praha, 4 Dětská klinika FN Olomouc, 5 Dětská klinika FN Hradec Králové, 6 I. dětská interní a onkologická klinika FN Brno, 7 Centrum 1
Published in: Transfuze Hematol. dnes,, 2002, No. 2, p. 55-58.
Category:

Overview

Acute lymphoblastic leukaemia (ALL)derived from mature B-cells is in fact generalized Burkitt ´slymphoma.Leukemic blasts are classified as L3 according to the FAB morphological classification.Theyare characterized by the presence of the surface immunoglobulins,most often IgM,and by a highproliferative rate.Current treatment comprising short blocks of intensive chemotherapy improvedremarkably the prognosis of this rare disease.Between VI/1990-XII/2000,ALL was diagnosed in 671children and adolescents aged 0 –18 years in the Czech Republic.B-ALL was found in 9 children (1.3 %).Complete remission was achieved in 77.8 %children.Four patients (44.4 %)suffered from early renalfailure which developed as a result of the tumour lysis syndrome.Neither death in remission nor relapsewere seen in this small group of patients.With a median follow-up of 3,7 years,the probability ofevent-free-survival is 75 %(SE 15 %).Therapeutic results of B-ALLin the Czech Republic are comparableto the results of the leading leukaemic study groups in the world.

Key words:
acute lymphoblastic leukaemia,mature-B-cells,treatment,children

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Labels
Haematology Internal medicine Clinical oncology
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