#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

A rare coexistence of hairy cell leukaemia and pregnancy: a case report


Authors: MUDr. Radan Doubek 1;  MUDr. Denisa Petrovová 1;  MUDr. Kateřina Sedláková 1;  prof. MUDr. Michael Doubek, Ph.D. 2
Authors‘ workplace: Gynekologicko-porodnická klinika LF MU a FN Brno 1;  Interní hematoonkologická klinika LF MU a FN Brno 2
Published in: Prakt Gyn 2008; 12(1): 14-16

Overview

The incidence is approximately 1 in 1,000 pregnancies. The incidence of leukemia coincident with pregnancy is reported at 1:75,000 to 1:100,000. Hairy cell leukemia (HCL) represents only 2 % of myeloproliferative disorders. It often presents with splenomegaly, hepatomegaly, lymphadenopathy, anaemia and trombocytopenia. The clinical manifestations are fatigue, infectious complications and haemorrhage. The diagnosis is based on the electrone microscopy and immunophenotyping of lymphocytes of peripheral blood and bone marrow. Treatment of pregnant patients with HCL is best accomplished with interferon alpha.

Case report:
29-year-old woman, the second pregnancy. Her hemoglobin, hematocrit and platelet count were all decreased (in the 12th week of present pregnancy). Hairy cell leukemia was diagnosed by the electrone microscopy and immunophenotyping of lymphocytes. Interferon alpha was administered and the labour was induced in the 39th week of pregnancy (without any complications). HCL occurring during pregnancy is totaly rare. In the pregnant population, 90 % of leukemias are classified as acute. In addition 80 % of patients with HCL are men at the age of fifty - fifty five.

Key words:
Hairy cell leukemia, immunophenotyping, interferon alpha, pregnancy


Sources

1. Pavlidis NA. Coexistence of pregnancy and malignancy. Oncologist 2002; 7: 279-287.

2. Hurley TJ, McKinnell JV, Irani MS. Hematologic malignancies in pregnancy. Obstet Gynecol Clin N Am 2005; 32: 595-614.

3. Kopeć I, Debski R, Samsel M et al. Hairy cell leukemia in pregnancy. Ginekol Pol 2005; 76: 898-901.

4. Adam Z, Vorlíček J. Vlasatobuněčná leukémie. In: Adam Z, Vorlíček J et al. Hematologie II, Přehled maligních hematologických nemocí. 1. ed. Praha: Grada 2001: 339-344.

5. Riccioni R, Galimberti S, Petrini M. Hairy cell leukemia. Curr Treat Options Oncol 2007; 8: 129-134.

6. Stiles GM, Stanco LM, Saven A et al. Splenectomy for hairy cell leukemia in pregnancy. J Perinatol 1998; 18: 200-201.

7. Swords R, Giles F. Hairy cell leukemia. Med Oncol 2007; 24: 7-15.

Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#