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Benefits of Sentinel Lymph Node Examination in Early Breast Carcinoma


Authors: M. Mýtnik;  J. Petrík;  J. Hanudeľ;  M. Wereb 1;  J. Klč 2;  Ľ. Straka 3
Authors‘ workplace: Chirurgická klinika FNsP Prešov, Slovenská republika, prednosta: MUDr. Miroslav Mýtnik, Ph. D. ;  Wesper s. r. o., Prešov, Slovenská republika, pracovisko nukleárnej medicíny, vedúci: MUDr. Mária Wereb 1;  Radiodiagnostické oddelenie FNsP Prešov, Slovenská republika, primár: MUDr. Miloslav Šimko, Ph. D. 2;  Klinická patológia s. r. o., Prešov, vedúci: MUDr. Ľubomír Straka, Ph. D. 3
Published in: Rozhl. Chir., 2011, roč. 90, č. 6, s. 343-347.
Category: Monothematic special - Original

Overview

Introduction:
Sentinel lymph node biopsy improves staging of disease, saves the axilla, and significantly reduces the risk of complications.

Material and methods:
The authors compare the two groups of surgical treatment of breast cancer patients - after conventional surgery with axillary exenteration with a group of patients with sentinel node biopsy using gamma probe with limited power.

Results:
In group of 42 patients after axillary exenteration authors observed: hematoma in 2 patients, 1 postoperative bleeding that need for surgical revision, 2 patients had paresthesia and 1 patient had lymphedema, which represents 11.5% of complications. In the group of 54 patients after limited exercise with the use of sentinel biopsy and gamma probe authors reported only one complication – an infected surgical wound seroma in the axilla (1.8% complications).

Conclusion:
Examination of sentinel node biopsy in combination with exact measurement of gamma probe allows friendly operating performance in the axilla and significantly reduces the incidence of postoperative complications.

Key words:
breast cancer – sentinel node – gamma probe – complication


Sources

1. Barclay, L., Vega, Ch. Lymphatic mapping, sentinel lymphadenectomy before neoadjuvant chemotherapy may be accurate in large breast cancer. Am. J. Surg., 2005; 190: 371–375.

2. Becker, H., Hohenberger, W., Junginger, T., et al. Chirurgická onkologie. 1. vyd. Praha, Grada. Publishing, a.s., 2005, s. 115–156.

3. Cabanes, P., Salmon, R., Vilcoq, J., et al. Value ofaxillary dissection in addition to lumpectomy and radiotherapy in early breast cancer. Lancet. 1992; 339: 1245–1248.

4. Galimberti, V., Veronesi, P., Arnone, P., et al. Stage migration after biopsy of internal mammary chain lymph nodes in breast cancer patients. Ann. Surg. Oncol., 2002; 9: 924–928.

5. Cipolla, C., Vieni, S., Fricano, S., et al. The accuracy of sentinel lymph node biopsy in the treatment of multicentric invasive breast cancer using a subareolar injection oftracer. World J. Surg., 2008; 32(11): 2483–2487.

6. De Freitas, R., et al. Acuracy of ultrasound and clinical examination in the diagnosis of axillary node metastasis in Brest cancer. Eur. Surg. Oncol., 2004; 17: 240.

7. Fait, V., Chrenko, V., Gatěk, J. Sentinelova biopsie u karcinomu prsu a neoadjuvantní chemoterapie. Klinická onkologie, 2005; 3: 77–79.

8. Guliano, A. E., Jones, R. C., Brennan, M., et al. Sentinel lymphadenectomy in breast cancer. J. Clin. Oncol., 1997; 15: 2345–2350.

9. Goyal, A., Newcombe, R. G., Mansel, R. E. Clinical relevance of multiplesentinel nodes in patients with breast cancer. Br. J. Surg., 2005; 92: 438–442.

10. Jakub, J., Diaz, N., Ebert., et al. Completion axillary lymph node dissection minimize the likehood of false negatives for patient with invasivebreast carcinoma and cytokeratin positive only sentinel lymph nodes. Am. J. Surg., 2002; 184: 301–302.

11. Julian, T., Dusi, D., Wolmark, N. Sentinel node biopsy after neoadjuvant chemotherapy for breast cancer Am. J. Surg., 2002; 184: 315–317.

12. Giuliano, A. Axillary node dissection unnecessary? 46 th annual meeting of American Society of Clinical Oncology, 2010: http://www.ecco-org.eu/News/News/EJC-News-5/ASCO-46th-Annual-Meeting/page.aspx/2396

13. Kroman, N., Holtweg, H., Wolfarth, et al. Effect of Breast-Conserving Therapy versus Radical Mastectomy on Prognosis for Young Women with Breast Carcinoma. Cancer, 2004; 100: 667–693.

14. Maza, S., Valencia, R., Geworski, L., et al. Peritumoural versus subareolar administration of technetium-99m nanocolloid for sentinel lymph node detection in breast cancer: preliminary results of a prospective intra-individual comparative study. Eur. J. Nucl. Med. Mol. Imaging, 2003; 30: 651–656.

15. Tuttle, T. M., Zogakis, T. G., Dunst, C. M. A review of technical aspects of sentinel lymph node identification for breast cancer. J. Am. Coll. Surg., 2002; 195: 261–268.

16. Rutletge, H., Davis, D., Chiu, R., et al. Sentinel node micrometastasis in Brest carcinoma may not be an indication for komplete axillaery dissection. Modern patology, 2005; 18: 762–768.

17. Schauer, A. J., Becker, W., Reiser, M., et al. The Sentinel Lymph Node Concept, Before Neoadjuvant Chemotherapy May Be Accurate inLarge Breast Cancers. Am. J. Surg., 2005; 190: 371–375.

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Surgery Orthopaedics Trauma surgery
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