Contribution of Mollecular Biology to the Diagnosis and Therapy of Colorectal Carcinoma – The Present and Future
Authors:
P. Pitule; V. Liška; V. Třeška; P. Novák; M. Čedíková *; M. Králíčková *
Authors‘ workplace:
Chirurgická klinika LF UK a FN v Plzni, přednosta: prof. MUDr. Vladislav Třeška, DrSc.
; Ústav histologie a embryologie LF UK v Plzni, přednostka: doc. MUDr. Jitka Kočová, CSc.
*
Published in:
Rozhl. Chir., 2011, roč. 90, č. 6, s. 315-323.
Category:
Monothematic special - Original
Overview
Colorectal cancer is one of the most frequent malignant disease and despite of the development of modern surgical and oncological treatment, it is still a very severe diagnosis for the patient. The survival of the patient after the radical surgery is mostly affected by the time of detection of the disease and by the selection of the appropriate oncological treatment. The effectivity of the oncological treatment depends mainly on the features of the malignant tissue. During the last decade, the importance of the molecular biology and it´s methodology have been growing for both detection of the disease and the selection of the best treatment for the individual patient. Genetic and epigenetic characteristics of the tumours helps to predict the prognosis of the disease and also select the best treatment, which extends the disease-free and overall survival of the patient. The presented review describes the most important molecular-biological characteristics with the prognostic or predictive function, which are used in the clinical practice or are in the later phase of clinical study.
Key words:
colorectal neoplasms – molecular biology methods – prognostic factors – predictive factors
Sources
1. Zavoral, M., Suchanek, S., Zavada, F., et al. Colorectal cancer screening in Europe. World J. Gastroenterol., 2009; 15(47): 5907–5915.
2. Pantel, K., Brakenhoff, R. H., Brandt, B. Detection, clinical relevance and specific biological properties of disseminating tumour cells. Nat. Rev. Cancer, 2008; 8(5): 329–340.
3. Paimela, H., Malila, N., Palva, T., et al. Early detection of colorectal cancer with faecal occult blood test screening. Br. J. Surg., 2010; 97(10): 1567–1571.
4. Ahlquist, D. A. Molecular detection of colorectal neoplasia. Gastroenterology, 2010; 138(6): 2127–2139.
5. Walther, A., Johnstone, E., Swanton, C., et al. Genetic prognostic and predictive markers in colorectal cancer. Nat. Rev. Cancer, 2009; 9(7): 489–499.
6. Cunningham, D., Humblet, Y., Siena, S., et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N. Engl. J. Med., 2004; 351(4): 337–345.
7. Amado, R. G., Wolf, M., Peeters, M., et al. Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J. Clin. Oncol., 2008; 26(10): 1626–1634.
8. Šácha, M., Havlíček, K., Sákra, L., et al. K-ras mutation as a prognostic factor in colorectal carcinoma. Rozhl. Chir., 2008; 87(1): 32–37.
9. Di Nicolantonio, F., Martini, M., Molinari, F., et al. Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer. J. Clin. Oncol., 2008; 26(35): 5705–5712.
10. Sartore-Bianchi, A., Martini, M., Molinari, F., et al. PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies. Cancer Res., 2009; 69(5): 1851–1857.
11. Prenen, H., De Schutter, J., Jacobs, B., et al. PIK3CA mutations are not a major determinant of resistance to the epidermal growth factor receptor inhibitor cetuximab in metastatic colorectal cancer. Clin. Cancer Res., 2009; 15(9): 3184–3188.
12. Sartore-Bianchi, A., Moroni, M., Veronese, S., et al. Epidermal growth factor receptor gene copy number and clinical outcome of metastatic colorectal cancer treated with panitumumab. J. Clin. Oncol., 2007; 25(22): 3238–3245.
13. Vobořil, R., Weberová-Vobořilová, J., Rychterová, V., et al. [NF-kappaB, colorectal carcinoma and radiotherapy: results of a clinical and experimental study]. Rozhl Chir., 2007; 86(5): 268–272.
14. De Roock, W., Claes, B., Bernasconi, D., et al. Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. Lancet Oncol., 2010; 11(8): 753–762.
15. Sargent, D. J., Marsoni, S., Thibodeau, S. N., et al. Confirmation of deficient mismatch repair (dMMR) as a predictive marker for lack of benefit from 5-FU based chemotherapy in stage II and III colon cancer (CC): A pooled molecular reanalysis of randomized chemotherapy trials. J. Clin. Oncol., 26: 2008 (May 20 suppl; abstr 4008).
16. Bibeau, F., Lopez-Crapez, E., Di Fiore, F., et al. Impact of Fc{gamma}RIIa-Fc{gamma}RIIIa polymorphisms and KRAS mutations on the clinical outcome of patients with metastatic colorectal cancer treated with cetuximab plus irinotecan. J. Clin. Oncol., 2009; 27(7): 1122–1129.
17. Braun, M. S., Richman, S. D., Quirke, P., et al. Predictive biomarkers of chemotherapy efficacy in colorectal cancer: results from the UK MRC FOCUS trial. J. Clin. Oncol., 2008; 26(16): 2690–2698. Erratum in: J. Clin. Oncol., 2008; 26(26): 4363.
18. Lurje, G., Manegold, P. C., Ning, Y., et al. Thymidylate synthase gene variations: predictive and prognostic markers. Mol. Cancer Ther., 2009; 8(5): 1000–1007.
19. Thorstensen, L., Lind, G. E., LŅvig, T., et al. Genetic and epigenetic changes of components affecting the WNT pathway in colorectal carcinomas stratified by microsatellite instability. Neoplasia, 2005; 7(2): 99–108.
20. Saridaki, Z., Georgoulias, V., Souglakos, J. Mechanisms of resistance to anti-EGFR monoclonal antibody treatment in metastatic colorectal cancer. World J. Gastroenterol., 2010; 16(10): 1177–1187.
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Perspectives in Surgery
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