Erdostein in Secretory Otitis Media
Authors:
L. Otruba 1; Richard Salzman 2; R. Kellnerová 3; Z. Hornáčková 1; M. Uhrová 2
Authors‘ workplace:
ORL klinika 3. LF UK a FNKV, Praha
1; Otolaryngologická klinika LF UP a FN Olomouc
2; Angelini Pharma, Česká republika, s. r. o., Brno
3
Published in:
Otorinolaryngol Foniatr, 64, 2015, No. 2, pp. 107-110.
Category:
Review Article
Overview
Non interventional post registration study dealing with the treatment of otitis media with effusion (OME). Erdosteine (brand name Erdomed) was administered during 2 months in the group of 42 children aged 3-18 years, 11 with cleft palate, 7 with the chronic form of OME. Evaluation was subjective – ear fullness and objective – oto microscopy, audiometry and tympanometry. Clinical effectiveness – subjective evaluation – ear fullness improved in 83 %. Improvement in objective evaluation - middle ear fluid presence in oto microscopy decreased in 81 % of cases, tympanometry – identification of A curve increased in 34 %, B curve decreased in 68 % of patients. Audiometry – finding of normal hearing increased in 22%, and of air - bone gap of 30 or more dB decreased in 13% of patients. Total treatment effectiveness assessed by physicians was very good in 57 %, and sufficient in 22 % of subjects. Safety and tolerance of Erdomed was declared excellent.
Keywords:
otitis media with effusion, Erdosteine, oto microscopy, tympanometry, audiometry
Sources
1. Dal Negro, R. W., Visconti, M., Micheletto, C., Tognella, S.: Changes in blood ROS, e-NO, and some pro-inflammatory mediators in bronchial secretions following Erdosteine or placebo: A controlled study in current smokers with mild COPD. Pulm. Pharmacol. Ther., 21, 2008, 2, s. 304-308.
2. Dal Negro, R. W.: Erdosteine: Antitussive and Anti-inflammatory effects. Lung, 186, 2008, Suppl 1, s. 70-73.
3. Griffin, G., Flynn, C. A.: Antihistamines and/or decongestants for otitis media with effusion (OME) in children. Cochrane Database Syst. Rev., 2011, 9, CD003423.
4. Hoza, J., Salzman, R., Stárek, I., Schalek, P., Kellnerová, R.: Erdosteine in the treatment of chronic rhinosinusitis with nasal polyposis – a pilot study. Rhinology, 51, 2013, 4, s. 323-327.
5. Jang, Y. Y., Song, J. H., Shin, Y. K., Han, E. S., Lee, Ch. S.: Depressant effects of Ambroxol and Erdosteine on cytokine synthesis, Granule Enzyxme Release and Free Radical Production in Rat Alveolar Macrophages Activated by Lipopolysacharide. Pharmacol. Toxicol., 92, 2003, 4, s. 173-179.
6. Sheahan, P., Blayney, A. W., Sheahan, J. N., Earley, M. J.: Sequellae of otitis media with effusion among children with cleft lip and/or cleft palate. Clin. Otolaryngol. Allied Sci., 27, 2002, 6, s. 494-500.
7. Simpson, S. A., Lewis, R., Van der Voort, J., Butler, C. C.: Oral or topical nasal steroids for hearing loss associated with otitis media with effusion in children. Cochrane Database Syst. Rev., 2011, 5, CD001935.
8. Šlapák, I. et al.: Dětská otolaryngologie. Mladá Fronta Praha, 2013, s. 58-61.
9. Tapiainen, T., Kujala, T., Renko, M., Koivunen, P., Kontiokari, T., Kristo, A., Pokka, T., Alho, O. P., Uhari, M.: Effect of antimicrobial treatment of acute otitis media on the daily disappearance of middle ear effusion: a placebo-controlled trial. JAMA Pediatr., 168, 2014, 7, s. 635-641.
Labels
Audiology Paediatric ENT ENT (Otorhinolaryngology)Article was published in
Otorhinolaryngology and Phoniatrics
2015 Issue 2
Most read in this issue
- Augmentation of Vocal Cords by Autologous Fat
- Present Diagnostics and Therapy of Inflammations of Maxillary Sinuses in the Czech Republic – Evaluation of a Questionnaire Survey
- Juvenile Recurrent Parotitis and Selective IgA Deficiency
- Massive Cervical Hematoma Developed Due to Spontaneous Rupture of External Carotid Artery