Pemphigus Vulgaris

Czech version

Authors: L. Vilkusová; P. Komínek; K. Zeleník; J. Dvořáčková
Authors‘ workplace: Klinika otorinolaryngologie FN Ostrava přednosta doc. MUDr. P. Komínek, Ph. D., MBA
Published in: Otorinolaryngol Foniatr, 57, 2008, No. 4, pp. 230-233.
Category: Case History

Overview

Pemphigus vulgaris is an autoimmune bullous disease affecting skin and mucosae covered by squamous epithelium. The first signs of the disease appear on oropharyngeal mucosa and can precede the main dermal symptoms by months or years. The symptoms in the oral cavity can imitate mycosis or aphthous stomatitis, with no response to standard treatment. If not giving a thought to pemphigus, this can put off the right diagnosis and the treatment and can lead to suffering of the patient. The treatment should be managed by the dermatologist and includes administration of corticosteroids and immunosuppressive drugs. The case of pemphigus vulgaris in a 78-year-old woman is described, the resemblance between erosions in the oral cavity and the oropharyngeal mycosis led to postponing of the diagnosis till the typical dermal morphs had appeared.

Key words:
pemphigus vulgaris, bullous disease, intraepidermal bullae, otolaryngologic manifestation, treatment.

Sources

1. Belšan, I., Jirásek, L., Kratochvílová, M., Bohut, V.: Pemphigus vulgaris jako paraneoplastický projev při bronchogenním karcinomu, Čs. Derm., 1980, s. 314-319.

2. Bharti, R.: Pemphigus erythematosus. Emedicine [online]. c2007, [cit. 2008-03-10]. Dostupný z < http://www.emedicine.com/derm/topic317.htm>.

3. Fassman, A., Dvořáková, N., Izakovičková-Hollá, L., Vaněk, J., Wotke, J.: Manifestation of pemphigus vulgaris in the oropfacial region. Case report. Scripta Medica (Brno), 2003, s. 55-62.

4. Helm, T. N.: Familial benign pemphigus (Hailey-Hailey Disease). Emedicine [online]. c2007, [cit. 2008-03-10]. Dostupný z <http://www.emedicine.com/derm/topic150.htm>.

5. Jautová, J., Jarčušková, D., Ficová, M., Dubivská, M.: Sérové imunoglobulíny a cirkulujúce imunokomplexy u pemphigus vulgaris. Čs. Derm., 70, 1995, s. 12-14.

6. Kovaľová, M., Jautová, J.: Pemphigus vulgaris nie len autoimúnny. Alergie, Supplementum, 2, 2004.

7. Schwartz, R. A.: Pemphigus foliaceus. Emedicine [online]. c2007, [cit. 2008-03-10]. Dostupný z < http://www.emedicine.com/derm/topic318.htm>.

8. Slezák, R.: Pemphigus vulgaris u mladé pacientky. Prakt. zubní Lék., 34, 1986, s. 236-239.

9. Tufano, M. A., Baroni, A., Buommino, E., Ruocco, E., Lombardi, M. L., Ruocco, V.: Detection of herpes-virus DNA in peripheral blood mononuclear cells and skin lesions of patients with pemphigus by polymerase chain reaction. Brit. J. Derm., 141, 1999, s. 1033-1039.

10. Zeina, B.: Pemphigus vulgaris. Emedicine [online]. c2007, [cit. 2008-03-10]. Dostupný z

<http://www.emedicine.com/derm/topic319.htm>.