The relation between age at menopause and age at first childbirth

Czech version

Authors: Anna Šťastná ^1,2; Jiřina Kocourková ²
Authors‘ workplace: Výzkumný ústav práce a sociálních věcí, v. v. i. ¹; Katedra demografie a geodemografie PřF UK ²
Published in: Čas. Lék. čes. 2023; 162: 330-336
Category: Original Article

Overview

Analysis of data from the representative "GGP – Contemporary Czech Family Survey" (2020–2022) on the population of women aged 40–69 years showed that the age of onset of menopause is associated with a low age at the birth of the first child. Women who had their first child before their 20th birthday, a pattern of reproductive behaviour common among generations of women before 1989, have an earlier onset of menopause than older first-time mothers. Conversely, the effect of higher age at first birth (35 years or more) on the delay of menopause has not been proved. However, this issue requires further investigation, as the sample analysed suggests certain tendencies. A larger sample size would be needed to make a conclusive finding.

Keywords:

menopause, age at menopause, age at first birth

Sources

Utian WH. The International Menopause Society menopause-related terminology definitions. Climacteric 1999; 2 (4): 284–286.
Thomas F, Renaud F, Benefice E et al. International variability of ages at menarche and menopause: patterns and main determinants. Hum Biol 2001; 73 (2): 271–290.
Stepaniak U, Szafraniec K, Kubínová R et al. Age at natural menopause in three central and eastern European urban populations: the HAPIEE study. Maturitas 2013; 75(1): 87–93.
Voorhuis M, Onland-Moret NC, van der Schouw YT et al. Human studies on genetics of the age at natural menopause: a systematic review. Hum Reprod Update 2010; 16: 364–377.
Snieder H, MacGregor AJ, Spector ID. Genes control cessation of a woman’s reproductive life: a twin study of hysterectomy and age at menopause. J Clin Endocrinol Met 1998; 83: 1875–1880.
Kok HS, van Asselt KM, van der Schouw YT et al. Genetic studies to identify genes underlying menopause age. Hum Reprod Update 2005; 11: 483–493.
Van Asselt KM, Kok HS, Pearson PL et al. Heritability of menopausal age in mothers and daughters. Fertil Steril 2004; 82: 1348–1351.
Dratva J, Gómez Real F, Schindler C et al. Is age at menopause increasing across Europe? Results on age at menopause and determinants from two population-based studies. Menopause 2009; 16 (2): 385–394.
Gottschalk MS, Eskild A, Hofvind S, Bjelland EK. The relation of number of childbirths with age at natural menopause: a population study of 310 147 women in Norway. Hum Reprod 2022; 37 (2): 333–340.
Bjelland EK, Hofvind S, Byberg L, Eskild A. The relation of age at menarche with age at natural menopause: a population study of 336 788 women in Norway. Hum Reprod 2018; 33 (6): 1149–1157.
Mishra GD, Pandeya N, Dobson AJ et al. Early menarche, nulliparity and the risk for premature and early natural menopause. Hum Reprod 2017; 32 (3): 679–686.
Roman Lay AA, do Nascimento CF, Horta BL, Dias Porto Chiavegatto Filho A. Reproductive factors and age at natural menopause: a systematic review and meta-analysis. Maturitas 2020; 131: 57–64.
Gold EB, Crawford SL, Avis NE et al. Factors related to age at natural menopause: longitudinal analyses from SWAN. Am J Epidemiol 2013; 178 (1): 70–83.
Dorjgochoo T, Kallianpur A, Gao YT et al. Dietary and lifestyle predictors of age at natural menopause and reproductive span in the Shanghai Women’s Health Study. Menopause 2008; 15: 924–933.
Nilsson P, Moller L, Koster A, Hollnagel H. Social and biological predictors of early menopause: a model for premature aging. J Intern Med 1997; 242: 299–305.
Sievert LL. Menopause as a measure of population health: an overview. Am J Hum Biol 2001; 13 (4): 429–433.
Zhu D, Chung HF, Dobson AJ et al. Age at natural menopause and risk of incident cardiovascular disease: a pooled analysis of individual patient data. Lancet Public Health 2019; 4 (11): e553–e564.
Jacobsen BK, Heuch I, Kvale G. Age at natural menopause and all-cause mortality: a 37-year follow-up of 19,731 Norwegian women. Am J Epidemiol 2003; 157: 923–929.
Gong D, Sun J, Zhou Y, Zou C, Fan Y. Early age at natural menopause and risk of cardiovascular and all-cause mortality: a meta-analysis of prospective observational studies. Int J Cardiol 2016; 203: 115–119.
Tao XY, Zuo AZ, Wang JQ, Tao FB. Effect of primary ovarian insufficiency and early natural menopause on mortality: a meta-analysis. Climacteric 2016; 19 (1): 27–36.
Huan L, Deng X, He M, Chen S, Niu W. Meta-analysis: early age at natural menopause and risk for all-cause and cardiovascular mortality. Biomed Res Int 2021; 15: 6636856.
Ossewaarde ME, Bots ML, Verbeek AL et al. Age at menopause, cause-specific mortality and total life expectancy. Epidemiology 2005; 16 (4): 556–562.
Xu WH, Xiang YB, Ruan ZX et al. Menstrual and reproductive factors and endometrial cancer risk: Results from a population-based case-control study in urban Shanghai. Int J Cancer 2004; 108 (4): 613–619.
Kaczmarek M. The timing of natural menopause in Poland and associated factors. Maturitas 2007; 57 (2): 139–153.
Zsakai A, Mascie-Taylor N, Bodzsar EB. Relationship between some indicators of reproductive history, body fatness and the menopausal transition in Hungarian women. J Physiol Anthropol 2015; 34: 35.
Fait T, Borovský M. DT56a in treatment of climacteric syndrome in the Central European population sample. Bratislavské lekárske listy 2021; 122 (5): 301–304.
Nedstrand E, Pertl J, Hammar M. Climacteric symptoms in a postmenopausal Czech population. Maturitas 1996; 23 (1): 85–89.
Pitha J, Auzký O, Kovář J et al. Changes in cardiovascular risk profile in women after menopause (Prague Pre and Post Menopausal Female study). Cor et Vasa 2014; 56 (2): e113–e117.
Burcin B, Kučera T. Dlouhodobý pokles a strukturální změny v úrovni úmrtnosti obyvatel České republiky. In: Bartoňová et al. Demografická situace České republiky. Proměny a kontexty 1993–2008. Sociologické nakladatelství, Praha, 2010.
Kocourková J, Slabá J, Šťastná A. The role of cohorts in the understanding of the changes in fertility in Czechia since 1990. AUC Geographica 2022; 57 (1): 61–74.
Age at menopause: number of births has only limited effect from interrupted ovulation. Focus on reproduction. ESHRE, 2021. Dostupné na: www.focusonreproduction.eu/article/News-in-Reproduction-Menopausal-age
Kocourková J, Šťastná A, Idlbeková B, Slabá J. Trendy plodnosti a potratovosti v Česku. Časopis lékařů českých 2023; 162 (7–8): 299–306.
Kreidl M, Šťastná A, Kocourková J et al. Czech Harmonized Generations and Gender Survey-II. Wave 1 (2020–2022). Version 1. 2023. Data obtained from the GGP Data Archive.
Kreidl M, Šťastná A, Hubatková B a kol. „Současná česká rodina“ dokumentace k datům. MUNI Press, Brno, 2023
Ruth KS, Perry JR, Henley WE et al. Events in early life are associated with female reproductive ageing: a UK Biobank study. Sci Rep 2016; 6: 24710.
Boulet MJ, Oddens BJ, Lehert P et al. Climacteric and menopause in seven South-east Asian countries. Maturitas 1994; 19 (3): 157–176.
Rizvanovic M, Balic D, Begic Z et al. Parity and menarche as risk factors of time of menopause occurrence. Med Arch 2013; 67 (5): 336–338.
Human Fertility Database. Max Planck Institute for Demographic Research (Germany) and Vienna Institute of Demography (Austria). Dostupné na: www.humanfertility.org
Rodstrom K, Bengtsson C, Lissner L, Bjorkelund C. Reproducibility of self-reported menopause age at the 24-year follow-up of a population study of women in Göteborg, Sweden. Menopause 2005; 12: 275–280.

Labels

Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management

Úvodem

Artificial intelligence in medicine and healthcare: Opportunity and/or threat

Zogala D. Artificial intelligence in medical imaging

Artificial intelligence’s contribution to early pulmonary lesion detection in chest X-rays: insights from two retrospective studies on a Czech population

Artificial intelligence in diabetic retinopathy screening: from idea to a medical device in clinical practice

Large language models are changing landscape of academic publications. A positive transformation?

Trends in fertility and abortion in Czechia

Changes in contraceptive behavior in Czechia

Reproductive plan of women in Czechia in the context of late reproductive regime and the COVID-19 pandemic

Infertility problems in the context of reproductive ageing

Questions and questionnaires about acute climacteric syndrome

Practical clinical recommendations for perioperative care in bariatric surgery 2023