#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Hypercapnic respiratory failure – review


Authors: Martin Vykopal 1;  Jan Mizera 1;  Petr Jakubec 1;  Samuel Genzor 1,2;  Pavol Pobeha 3
Authors‘ workplace: Klinika plicních nemocí a tuberkulózy LF UP a FN Olomouc 1;  Centrum digitálního zdravotnictví LF UP a FN Olomouc 2;  Klinika pneumológie a ftizeológie LF UPJŠ a UNLP Košice 3
Published in: Čas. Lék. čes. 2023; 162: 13-18
Category: Review Article

Overview

This review summarizes the issue of acute hypercapnic respiratory failure. Acute respiratory failure is a condition in which the respiratory system is unable to fulfill its basic function, i.e. enriching the blood with oxygen and excreting carbon dioxide. Chronologically, we divide it into acute and chronic, and according to the manifestation into hypoxemic or hypoxemic with hypercapnia. Multiple factors, such as reduced ventilation and increased dead space, contribute to the development of hypoxemic-hypercapnic (global) respiratory failure. Both the patient's clinical presentation and laboratory examination of blood gases and acid-base balance (preferably from arterial blood) are used for diagnosis. In the absence of contraindications, non-invasive ventilation is used to establish normocapnia.

Keywords:

Respiratory failure – hypercapnia – noninvasive ventilation


Sources
  1. Vonderbank S, Gibis N, Schulz A et al. Hypercapnia at hospital admission as a predictor of mortality. Open Access Emerg Med 2020; 12: 173–180.
  2. Gendreau S, Geri G, Pham T et al. The role of acute hypercapnia on mortality and short-term physiology in patients mechanically ventilated for ARDS: a systematic review and meta-analysis. Intensive Care Med 2022; 48: 517–534.
  3. Chung Y, Garden FL, Marks GB, Vedam H. Causes of hypercapnic respiratory failure and associated in‐hospital mortality. Respirology 2023; 28: 176–182.
  4. Caruso ALG, Bouillon TW, Schumacher PM et al. Drug-induced respiratory depression: an integrated model of drug effects on the hypercapnic and hypoxic drive. Annu Int Conf IEEE Eng Med Biol Soc 2007; 2007: 4259–4263. 
  5. Vadász I, Hubmayr RD, Nin N et al. Hypercapnia: a nonpermissive environment for the lung. Am J Respir Cell Mol Biol 2012; 46: 417–421.
  6. Patel S, Sharma S. Respiratory acidosis. StatPearls, Treasure Island, 2022.
  7. Fox BD, Bondarenco M, Shpirer I et al. Transitioning from hospital to home with non-invasive ventilation: who benefits? Results of a cohort study. BMJ Open Respir Res 2022; 9: e001267.
  8. Blankenburg T, Benthin C, Pohl S et al. Survival of hypercapnic patients with copd and obesity hypoventilation syndrome treated with high intensity noninvasive ventilation in the daily routine care. Open Respir Med J 2017; 11: 31–40.
  9. Lněnička J. Respirační insuficience, chronická hyperkapnie a domácí neinvazivní ventilace z pohledu pneumologa. Vnitřní lékařství 2021; 67: 323–327.
  10. Tucker AM, Johnson TN. Acid‐base disorders: a primer for clinicians. Nutr Clin Pract 2022; 37: 980–989.
  11. Plant PK. One year period prevalence study of respiratory acidosis in acute exacerbations of COPD: Implications for the provision of non-invasive ventilation and oxygen administration. Thorax 2000; 55: 550–554.
  12. Resta O, Barbaro MPF, Brindicci C et al. Hypercapnia in overlap syndrome: Possible determinant factors. Sleep Breath 2002; 6(1): 11–17.
  13. Kolek V, Kašák V, Koziar Vašková M. Pneumologie (3., rozšířené vyd.). Maxdorf, Praha, 2017.
  14. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. Global Initiative for Chronic Obstructive Lung Disease, 2023. Dostupné na: https://goldcopd.org/wp-content/uploads/2023/03/GOLD-2023-ver-1.3-17Feb2023_WMV.pdf
  15. Saure EW, Eagan TML, Jensen RL et al. Explained variance for blood gases in a population with COPD. Clin Respir J 2012; 6: 72–80.
  16. Rodríguez-Roisin R, Drakulovic M, Rodríguez DA et al. Ventilation-perfusion imbalance and chronic obstructive pulmonary disease staging severity. J Appl Physiol 2009; 106: 1902–1908.
  17. Briva A, Vadász I, Lecuona E et al. High co2 levels impair alveolar epithelial function independently of pH. PLoS One 2007; 2: e1238.
  18. Dave C, Wharton S, Mukherjee R et al. Development and relevance of hypercapnia in COPD. Can Respir J 2021: 6623093.
  19. Rochwerg B, Brochard L, Elliott MW et al. Official ERS/ATS clinical practice guidelines: noninvasive ventilation for acute respiratory failure. Eur Respir J 2017; 50: 1602426.
  20. Brochard L, Isabey D, Piquet J et al. Reversal of acute exacerbations of chronic obstructive lung disease by inspiratory assistance with a face mask. N Engl J Med 1990; 323: 1523–1530.
  21. Brochard L, Mancebo J, Wysocki M et al. Noninvasive ventilation for acute exacerbations of chronic obstructive pulmonary disease. N Engl J Med 1995; 333: 817–822.
  22. Ambrosino N, Foglio K, Rubini F et al. Non-invasive mechanical ventilation in acute respiratory failure due to chronic obstructive pulmonary disease: correlates for success. Thorax 1995; 50: 755–757.
  23. Wang S, Singh B, Tian L et al. Epidemiology of noninvasive mechanical ventilation in acute respiratory failure-a retrospective population-based study. BMC Emerg Med 2014; 13: 6.
  24. Masa JF, Pépin JL, Borel JC et al. Obesity hypoventilation syndrome. Eur Respir Rev 2019; 28: 180097.
  25. Lněnička J, Dostálová S, Doušová T a kol. Doporučený postup pro domácí neinvazivní ventilaci. Stud Pneumol Phtiseol 2022; 82: 168–184.
  26. Chebib N, Nesme P, Freymond N et al. Acute respiratory failure in obesity-hypoventilation syndrome managed in the ICU. Respir Care 2019; 64: 1545–1554.
  27. Nicolini A, Ferrando M, Solidoro P et al. Non-invasive ventilation in acute respiratory failure of patients with obesity hypoventilation syndrome. Minerva Med 2018; 109 (6 Suppl. 1): 1–5.
  28. Comellini V, Pacilli AMG, Nava S. Benefits of non‐invasive ventilation in acute hypercapnic respiratory failure. Respirology 2019; 24: 308–317.
  29. Iqbal MA, Gupta M. Cardiogenic pulmonary edema. StatPearls, Treasure Island, 2022.
  30. Masip J. Noninvasive ventilation in acute heart failure. Curr Heart Fail Rep 2019; 16: 89–97.
  31. Faqihi BM, Trethewey SP, Morlet J et al. Bilevel positive airway pressure ventilation for non-COPD acute hypercapnic respiratory failure patients: A systematic review and meta-analysis. Ann Thorac Med 2021; 16: 306–322.
  32. Wilson KC, Saukkonen JJ. Acute respiratory failure from abused substances. J Intensive Care Med 2004; 19: 183–193.
  33. Kreppein U, Litterst P, Westhoff M. Hyperkapnisches Atemversagen. Med Klin Intensivmed Notfmed 2016; 111: 196–201.
  34. Osadnik CR, Tee VS, Carson-Chahhoud KV et al. Non-invasive ventilation for the management of acute hypercapnic respiratory failure due to exacerbation of chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2017; 7: CD004104.
  35. Bourke SC, Bullock RE, Williams TL et al. Noninvasive ventilation in ALS: Indications and effect on quality of life. Neurology 2003; 61: 171–177.
  36. Gören NZ, Şancı E, Ercan Coşkun FF et al. Comparison of BPAP S/T and average volume-assured pressure support modes for hypercapnic respiratory failure in the emergency department: A randomized controlled trial. Balkan Med J 2021; 38: 265–271.
  37. Papachatzakis Y, Nikolaidis PT, Kontogiannis S. High-flow oxygen through nasal cannula vs. non-invasive ventilation in hypercapnic respiratory failure: A randomized clinical trial. Int J Environ Res Public Health 2020; 17: 5994.
  38. Sun J, Li Y, Ling B et al. High flow nasal cannula oxygen therapy versus non-invasive ventilation for chronic obstructive pulmonary disease with acute-moderate hypercapnic respiratory failure: an observational cohort study. Int J Chron Obstruct Pulmon Dis 2019; 14: 1229–1237.
  39. Ghosh D, Elliott MW. Acute non-invasive ventilation – getting it right on the acute medical take. Clin Med 2019; 19: 237–242.
  40. Bräunlich J, Turba K, Wirtz H. Reversibility of hypercapnia after an acute exacerbation of COPD. Respiration 2022; 101: 816–822.
Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#