#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#
CS
proLékaře.cz / Journals / Journal of Czech Physicians / 2020 - 7-8

Season of the year, vitamin D and COVID-19

Czech version

Authors: Miloslav Kopeček 1,2;  Cyril Höschl 1,2
Authors‘ workplace: Národní ústav duševního zdraví, Klecany 1;  Klinika psychiatrie a lékařské psychologie 3. LF UK v Praze 2
Published in: Čas. Lék. čes. 2020; 159: 312-316
Category: Review Article

Overview

Vitamin D supplementation reduced the risk of acute respiratory tract infection in two meta-analyses. Mendelian randomization shows a causal effect of low vitamin D on bacterial pneumonias risk. These studies involved patients before COVID-19 pandemic. Several association studies found higher incidence of SARS-CoV-2 positivity, greater COVID-19 severity and higher risk of mortality in vitamin D deficient subjects compared to vitamin D non-deficient controls.

We draw attention to the trend of inverse relative COVID-19 mortality in Europe versus the states of the Southern Hemisphere (Australia, Brazil, South Africa) in dependence on season, which may be associated with intensity of ultraviolet radiation and consequent seasonal fluctuation of serum vitamin D levels. Although we cannot yet confirm causal role of vitamin D in SARS-CoV-2 positivity or COVID-19, we recommend consumption of vitamin D rich food or vitamin D supplementation in the non-sunny season to prevent vitamin D deficiency.

Keywords:

COVID-19 – SARS-CoV-2 – vitamin D

Sources
  1. Martineau AR, Forouhi NG. Vitamin D for COVID-19: a case to answer? Lancet Diabetes Endocrinol 2020; 8: 735-736.
  2. Martineau AR, Jolliffe DA, Hooper RL et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ 2017; 356: i6583.
  3. Jolliffe DA, Camargo CA jr., Sluyter JD et al. Vitamin D supplementation to prevent acute respiratory infections: systematic review and meta-analysis of aggregate data from randomised controlled trials. medRxiv 2020, doi: 10.1101/2020.07.14.20152728.
  4. Merzon E, Tworowski D, Gorohovski A et al. Low plasma 25(OH) vitamin D level is associated with increased risk of COVID-19 infection: an Israeli population-based study. FEBS J 2020; 287: 3693–3702.
  5. D'Avolio A, Avataneo V, Manca A et al. 25-hydroxyvitamin D concentrations are lower in patients with positive PCR for SARS-CoV-2. Nutrients 2020; 12: 1359.
  6. Meltzer DO, Best TJ, Zhang H. Association of vitamin D status and other clinical characteristics with COVID-19 test results. JAMA Netw Open 2020; 3: e2019722.
  7. Kaufman HW, Niles JK, Kroll MH et al. SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels. PLoS One 2020; 15(9): e0239252.
  8. Hastie CE, Pell JP, Sattar N. Vitamin D and COVID-19 infection and mortality in UK Biobank. Eur J Nutr 2020, doi: 10.1007/s00394-020-02372-4.
  9. Carpagnano GE, Di Lecce V, Quaranta VN et al. Vitamin D deficiency as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19. J Endocrinol Invest 2020, doi: 10.1007/s40618-020-01370-x.
  10. Hars M, Mendes A, Serratrice C et al. Sex-specific association between vitamin D deficiency and COVID-19 mortality in older patients. Osteoporos Int 2020; 31: 2495-2496.
  11. Panagiotou G, Tee SA, Ihsan Y et al. Low serum 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalized with COVID-19 are associated with greater disease severity. Clin Endocrinol (Oxf) 2020; 93: 508–511.
  12. Kun Ye, Fen Tang, Xin Liao et al. Does serum vitamin D level affect COVID-19 infection and its severity? A case-control study. J Am Coll Nutr 2020, doi: 10.1080/07315724.2020.1826005.
  13. Faul JL, Kerley CP, Love B et al. Vitamin D deficiency and ARDS after SARS-CoV-2 Infection. Ir Med J 2020; 113: 84.
  14. Karahan S, Katkat F. Impact of serum 25(OH) vitamin D level on mortality in patients with COVID-19 in Turkey. J Nutr Health Aging 2020, doi: 10.1007/s12603-020-1479-0.
  15. Radujkovic A, Hippchen T, Tiwari-Heckler S et al. Vitamin D deficiency and outcome of COVID-19 patients. Nutrients 2020; 12: 2757.
  16. Pizzini A, Aichner M, Sahanic S et al. Impact of vitamin D deficiency on COVID-19-a prospective analysis from the CovILD registry. Nutrients 2020; 12: E2775.
  17. Ferrari D, Locateli M. No significant association between vitamin D and COVID-19. A retrospective study from a northern Italian hospital. Int J Vitam Nutr Res 2020, doi: 10.1024/0300-9831/a000687.
  18. Hernández JL, Nan D, Fernandez-Ayala M et al. Vitamin D status in hospitalized patients with SARS-CoV-2 infection. J Clin Endocrinol Metab 2020, doi: 10.1210/clinem/dgaa733.
  19. Cereda E, Bogliolo L, Klersy C et al. Vitamin D 25OH deficiency in COVID-19 patients admitted to a tertiary referral hospital. Clin Nutr 2020, doi: 10.1024/0300-9831/a000687.
  20. Kraus FB, Medenwald D, Ludwig-Kraus B. Do extreme summers increase blood vitamin D (25-hydroxyvitamin D) levels? PLoS One 2020;15: e0242230.
  21. Çolak Y, Nordestgaard BG, Afzal S. Low vitamin D and risk of bacterial pneumonias: Mendelian randomisation studies in two population-based cohorts. Thorax 2020, doi: 10.1136/thoraxjnl-2020-215288.
  22. Butler-Laporte G, Nakanishi T, Mooser V et al. Vitamin D and COVID-19 susceptibility and severity: a Mendelian randomization study. Int J Epidemiol 2020, doi: 10.1093/ije/dyaa229.
  23. Liu D, Tian Q, Zhang J et al. Association of 25 hydroxyvitamin D concentration with risk of COVID-19: a Mendelian randomization study. medRxiv 2020, doi: 10.1101/2020.08.09.20171280.
  24. Li X, van Geffen J, van Weele M et al. Genetically-predicted vitamin D status, ambient UVB during the pandemic and COVID-19 risk in UK Biobank: Mendelian randomisation study. medRxiv 2020, doi: 10.1101/2020.08.18.20177691.
  25. Moozhipurath RK, Kraft L, Skiera B. Evidence of protective role of ultraviolet-B (UVB) radiation in reducing COVID-19 deaths. Sci Rep 2020; 10: 17705.
  26. Karohl C, Su S, Kumari M et al. Heritability and seasonal variability of vitamin D concentrations in male twins. Am J Clin Nutr 2010; 92: 1393-1398.
  27. Castillo ME, Entrenas Costa LM, Vaquero Barrios JM et al. Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: a pilot randomized clinical study. J Steroid Biochem Mol Biol 2020; 203: 105751.
  28. Quesada-Gomez JM, Bouillon R. Is calcifediol better than cholecalciferol for vitamin D supplementation? Osteoporos Int 2018; 29: 1697-1711.
  29. Annweiler C, Hanotte B, de l'Eprevier CG et al. Vitamin D and survival in COVID-19 patients: a quasi-experimental study. J Steroid Biochem Mol Biol 2020; 204: 105771.
  30. Annweiler G, Corvaisier M, Gautier J et al. Vitamin D supplementation associated to better survival in hospitalized frail elderly COVID-19 patients: the GERIA-COVID quasi-experimental study. Nutrients 2020; 12: E3377.
  31. Murai IH, Fernandes Al, Sales LP et al. Effect of vitamin D3 supplementation vs placebo on hospital length of stay in patients with severe COVID-19: a multicenter, double-blind, randomized controlled trial. medRxiv 2020, doi: 10.1101/2020.11.16.20232397.
  32. Ihln M, Kožený J, Kopeček M. Význam vitaminu D a jeho sérové koncentrace u psychiatrických pacientů v jednotlivých měsících roku. Psychiatrie 2020; 24: 152-162.
  33. World Health Organization. WHO Coronavirus disease (COVID-19) Situation report 133. WHO, 1. 7. 2020. Dostupné na: www.who.int/docs/default-source/coronaviruse/situation-reports/20200601-covid-19-sitrep-133.pdf?sfvrsn=9a56f2ac_4
  34. World Health Organization. WHO Coronavirus Disease (COVID-19) Dashboard. WHO, 2020. Dostupné na: https://covid19.who.int
  35. Šterzl I, Pikner R. Deficit vitaminu D a imunitní funkce. Medicína pro praxi 2019; 16: 318–322.
  36. Seyran M, Pizzol D, Adadi P et al. Questions concerning the proximal origin of SARS-CoV-2. J Med Virol 2020, doi: 10.1002/jmv.26478.
  37. Cavaleros M, Buffenstein R, Ross FP et al. Vitamin D metabolism in a frugivorous nocturnal mammal, the Egyptian fruit bat (Rousettus aegyptiacus). Gen Comp Endocrinol 2003; 133: 109-117.
  38. Southworth LO, Holick MF, Chen TC et al. Effects of sunlight on behavior and 25-hydroxyvitamin D levels in two species of Old World fruit bats. Dermatoendocrinol 2013; 5: 192–198.
  39. Waldron JL, Ashby HL, Cornes MP et al. J Clin Pathol 2013; 66: 620-622.
  40. European Food Safety Agency. Dietary reference values for vitamin D. EFSA Journal 2016; 14: 4547.
  41. Vyskočil V. Vitamin D. Klinická farmakologie a farmacie 2011; 25: 72–75.
Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management
Crucial moments in Czechoslovak radiobiology history
Biological effects of ionizing radiation
Modern trends in radiotherapy
DNA repair in head and neck tumor cells and possibilities of its monitoring to estimate individual tumor radioresistance and selection of optimal primary treatment
Trends in pharmacological stimulation of regeneration of ionizing radiation-damaged mammalian organism
Biological dosimetry and modern (-omic) methods
Advances in research of DNA damage and repair in cells exposed to various types of ionizing radiation in the era of super-resolution optical microscopy
Principles and new perspectives in the vaccination against SARS-CoV-2 virus
Age is not a disease: Evolution of protective antibodies against SARS-CoV-2 in seniors from the Břevnice nursing home
Úvodem
Editorial
Article was published in

Journal of Czech Physicians

Issue 7-8
2020 Issue 7-8
Download issue PDF
Most read in this issue
Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#