Lymph node syndrome associated with cat scratch disease in children and adults
Authors:
Lubomíra Hozáková 1,2; Luděk Rožnovský 2; Fádi Fakhouri 3; Jana Doležílková 4; Vladimír Janout 5
Authors‘ workplace:
Ústav epidemiologie a ochrany veřejného zdraví LF OU, Ostrava
1; Klinika infekčního lékařství LF OU a FN Ostrava
2; Ústav patologie LF OU a FN Ostrava
3; Oddělení parazitologie a lékařské zoologie, Zdravotní ústav se sídlem v Ostravě
4; Fakulta zdravotnických věd UP Olomouc
5
Published in:
Čas. Lék. čes. 2018; 157: 146-151
Category:
Original Articles
Overview
A retrospective evaluation of a group of patients with cat-scratch disease which is focused on epidemiological context, clinical picture, serological diagnosis and treatment in children and adults. Seventy-three patients with catch-scratch disease (CSD) were diagnosed at the Clinic of infectious medicine in 2008–2017, the group consisted of 37 children and 36 adults. Injury, or at least contact with cat, localization of lymph node syndrome and other clinical signs were investigated. Serological diagnosis was based on detection of IgM and IgG antibodies against Bartonella henselae. Duration of lymph node syndrome and antibodies against B. henselae were observed. Findings of granulomatous inflammation in extirpated lymph node supported suspicion of CSD.
66 of 73 patients had contact with cat, only 22 patients reported injury caused by cat. Cervical lymph nodes were affected the most often, in 32 patients. Extirpation of lymph node was performed in 19 patients. Positive IgM antibodies were detected in 47 patients. Between the group of children and adults important differences in any followed parameters were not observed.
In the group of 73 patients with cat-scratch disease cervical lymph nodes were affected the most often. Positive IgM antibodies were detected in 47 patients, lymph node extirpation was performed in 19 patients. Considerable differences in course of disease in children and adults were not found out.
Keywords:
cat-scratch disease, lymph node syndrome, serology, extirpation
Sources
1. Pennisi MG, Marsilio F, Hartmann K et al. Bartonella species infection in cats. ABCD guidelines on prevention and management. J Feline Med Surg 2013; 15(7): 563–569.
2. Oteo JA, Maggi R et al. Prevalence of Bartonella spp. By culture, PCR and serology, in veterinary personnel from Spain. Parasit Vectors 2017; 10(1): 553.
3. Nelson CA, Moore AR et al. Cat scratch disease: U. S. clinicians’ experience and knowledge. Zoonoses Public Health 2018; 65(1): 67–73.
4. Melter O. Novinky v problematice bartonelových infekcí. Klinická mikrobiologie a infekční lékařství 2013; 9 (2): 36–44.
5. Herčík K, Hásová V, Janeček J et al. Molecular evidence of Bartonella DNA in ixodid ticks in Czechia. Folia Microbiol 2007; 52 (5): 503–509.
6. Bergmann M, Englert T et al. Prevalence of Bartonella species infections in cats in Southern Germany. Vet Rec 2017; 180 (13): 325.
7. Day MJ. Pet-related infections. Am Fam Physician 2016; 94 (10): 794–802.
8. Baranowski K, Huang B. Cat scratch disease. StatPearls, Treasure Island, 2018. Dostupné na: www.ncbi.nlm.nih.gov/books/NBK482139
9. Chen Y, Fu YB, Xu XF et al. Lymphadenitis associated with cat-scratch disease simulating a neoplasm: Imaging findings with histopathological associations. Oncol Lett 2018; 15 (1): 195–204.
10. Illman JE, Terra SB et al. Granulomatous diseases of the breast and axilla: radiological findings with pathological correlation. Insights Imaging 2018; 9 (1): 59–71.
11. Lindeboom JA. Pediatric cervicofacial lymphadenitis caused by Bartonella henselae. Oral Surg Oral Med Oral Patho Oral Radiol 2015; 120 (4): 469–473.
12. Shasha D, Gilon D, Vernea F et al. Visceral Cat Scratch Disease with Endocarditis in an Immunocompetent Adult: A Case Report and Review of the Literature. Vector Borne Zoonotis Dis 2014; 14 (3): 175–181.
13. Melewska KM, Mania A et al. Cat-scratch disease: a wide spectrum of clinical pictures. Postepy Dermatol Alergol 2015; 32 (3): 216–220.
14. Schattner A, Uliel L, Dubin I. The cat did it: erythema nodosum and additional atypical presentations of Bartonella henselae infection in immunocompetent hosts. BMJ Case Rep 2018, pii: bcr-2017-222511.
15. Burzo ML, Antonelli M, Pecorini G. Fever of unknown origin and splenomegaly. Medicine (Baltimore) 2017; 96 (50): e9197.
16. Slater LN, Welch DF. Bartonella, including Cat-Scratch Disease. In: Mandell, Douglas, and Bennett (eds.). Principles and Practice of Infectious diseases (6th ed.). Elsevier, Philadelphia, 2005. 2733–2748.
17. Kwon HY, Im JH Lee SM. The seroprevalence of Bartonella henselae in healthy adults in Korea. Korea J Intern Med 2017; 32 (3): 530–535.
18. High K, Van Meter J. An 8-year-old Boy with altered mental status. Air Med J 2015; 34 (3): 149–151.
19. Zenone T. Systemic Bartonella henselae Infection in Immunocompetent Adult Presenting as Fever of Unknown Origin. Case Rep Med 2011; 2011: 183937.
20. Oray M, Önal S, Koç Akbay A, Tuğal Tutkun İ. Diverse clinical signs of ocular involvement in cat scratch disease. Turk J Ophtalmo 2017; 47(1): 9–17.
21. Barson WJ, Honegger JR, Texter K. Acute myopericarditis associated with cat scratch disease in an adolescent. Pediatr Infect Dis J 2014; 33(9): 982–984.
22. Ulug M. Evaluation of cat scratch disease reported from Turkey between 1996 and 2013 and review of the literature of the literature. Centr Eur J Public Health 2015; 23(2): 170–175.
23. Gradidge E, Chauhan A, Stelle RW et al. Fever, lymphadenopathy, and splenomegaly: did the cat do it? Clin Pediatr (Phila) 2013; 52 (11): 1072–1074.
24. Hozáková L, Rožnovský L, Franková H. Felinóza – stále aktuální zoonóza. Klinická mikrobiologie a infekční lékařství 2014; 20 (1): 4–10.
25. Kimura A, Hasegawa S, Yanagihara M et al. Cat-scratch disease with severe pleuritis in a 6-year-old girl. Pediatr Int 2015; 57 (3): 501–503.
26. Jabcuga CE, Jin L, Macon WR et al. Broadening the morphologic spectrum of Bartonela henselae lymphadenitis. Analysis of 100 molecularly characterized cases. Am J Surg Pathol 2016; 40 (3): 342–347.
27. Sendi P, Hirzel C, Cloch A. Bartonella-associated transverse myelitis. Emerg Infect Dis 2017; 23(4): 712–713.
28. King KY, Hicks MJ, Mazziotti MV et al. Persistent cat scratch disease requiring surgical excision in a patient with MPGN. Pediatrics 2015; 135 (6): e 1514-7.
29. Nelson CA, Saha S, Mead PS. Cat-scratch disease in the United States, 2005–2013. Emerg Infect Dis 2016; 22 (10): 1841–1846.
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Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain managementArticle was published in
Journal of Czech Physicians
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