Early detection of sporadic pancreatic cancer
Authors:
prof. MUDr. Přemysl Frič, DrSc. 1; prof. MUDr. Aleksi Šedo, DrSc. 2; prof. MUDr. Jan Škrha, DrSc. 3; Mba; prof. MUDr. Tomáš Zima, DrSc. 4; Mba; MUDr. Petr Bušek, Ph.D. 2; MUDr. Pavel Škrha 5; MUDr. Klára Kmochová 1; MUDr. Martin Laclav 1; MUDr. Bohuš Bunganič 1; prof. MUDr. Miroslav 1; Zavoral, Ph.D.
Authors‘ workplace:
Interní klinika 1. LF UK a ÚVN – Vojenské fakultní nemocnice, Praha
1; Ústav biochemie a experimentální onkologie 1. LF UK v Praze.
2; 3. interní klinika – klinika endokrinologie a metabolismu 1. LF UK a
VFN v Praze
3; Ústav lékařské biochemie a laboratorní diagnostiky 1. LF UK a VFN v
Praze
4; 2. interní klinika 3. LF UK a FN Královské Vinohrady, Praha
5
Published in:
Čas. Lék. čes. 2016; 155: 44-47
Category:
Review Articles
Overview
Pancreatic cancer (PC) behaves very differently in comparison with other malignancies. Its prevalence continuously increases, mortality does not decrease, diagnosis is frequently late, radical surgery is limited to 15–20 % of patients, postoperative relapses are frequent, and chemotherapy has a palliative character. Preventive programs are the only possibility of improvement. In familial pancreatic cancer (FPC) the knowledge of the genetic mutation enables earlier entry of specialists into the surveillance program. The repeated use of high resolution imaging methods (including endoscopy and pancreatic cytology) may be followed by more frequent detection of the precursors and earlier stages of FPC. The identification of sporadic pancreatic cancer (SPC) depends fully on the construction of a multi-step and multi-disciplinary preventive program.
Keywords:
sporadic pancreatic cancer, risk factors, pancreatogenic diabetes, early symptoms, early detection, risk groups
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