Autophagy and its role in protective and damaging inflammatory response
Authors:
Jan Krejsek; Lucia Hrnčířová; Drahomíra Holmannová; Irena Berglová; Mouhammed Abuattieh; Ctirad Andrýs
Authors‘ workplace:
Univerzita Karlova v Praze, Lékařská fakulta v Hradci Králové, Ústav klinické imunologie a alergologie FN
Published in:
Čas. Lék. čes. 2012; 151: 128-134
Category:
Review Articles
Overview
Autophagy is an integral part of cell strategy to overcome adverse living conditions. Moreover, autophagy participates in the protection of cytoplasm against invasion of the intracellular pathogenic bacteria. Abnormalities in the autophagy are participating on the inability of Crohn’s disease patients to maintain gut microbiome homeostasis ultimating in the development of immunopathological reaction in these patients. Autophagy can enhance the survival of autoreactive T cells in multiple sclerosis patients thus contributing to the disease induction and progression.
Key words:
autophagy, immunity, inflammation, multiple sclerosis, Crohn’s disease.
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Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain managementArticle was published in
Journal of Czech Physicians
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