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Sexually transmitted infections and spermicides


Authors: Daniel Driák
Authors‘ workplace: Gynekologicko-porodnická klinika, 1. lékařská fakulta Univerzity Karlovy v Praze a Nemocnice Na Bulovce
Published in: Čas. Lék. čes. 2012; 151: 459-462
Category: Review Article

Overview

Incidence of sexually transmitted infections (diseases) has been already increasing again for more than one decade; the world number of 125-340 millions of new cases a year is estimated. Fifteen thousands of new HIV-positive persons daily present a substantial contribution to the total amount. Besides an increasing number of unplanned pregnancies, the huge spreading of sexually transmitted infections predominantly of the second generation is the main reason for a renewed interest in search of local contraceptives, i.e. spermicides. An urgent need for a new, non-detergent, synthetic or natural spermicide emerged to replace the traditional nonoxynol-9. New preparation of microbicidal spermicide should offer dual protection against both unplanned conception and sexually transmitted infections.

Key words:
sexually transmitted infections, sexually transmitted diseases, spermicides, nonoxynol-9, non-detergent compound, antimicrobial peptides.


Sources

1. Greenhouse P. Integrated sexual health service. Eur J Contracept Reprod Health Care 2004; 9: 13.

2. Wulff M, et al. The condom in relation to prevention of sexually transmitted infections and as a contraceptive methos in Sweden. Eur J Contracept Reprod Health Care 2004; 9: 69–77.

3. Gregorová P, et al. Antikoncepční chování českých žen: Výsledky národního výzkumu. Čes Gynek 2010; 75: 141–148.

4. Líbalová Z, et al. Vulvovaginitida. Výskyt a význam smíšených a „nezařaditelných” obrazů. Čes Gynek 2007; 72: 32–37.

5. D’Cruz OJ, et al. Clinical development of microbicides for the prevention of HIV infection. Curr Pharm Des 2004; 10: 315–336.

6. Mitchell HS, et al. Contraception choice for HIV positive women. Sex Transm Infect 2004; 80: 167–173.

7. Čepický P, et al. Pohlavní přenos vulvovaginitid. Mod Gynek Porod 2006; 15: 420–423.

8. Unzeitig V. Bariérová a chemická antikoncepce. Mod Gynek Porod 1997; 6: 431–439.

9. Yedery RD, et al. Antimicrobial peptides as microbicidal contraceptives: prophecies for prophylactics –a mini review. Eur J Contracept Reprod Health Care 2005; 10: 32–42.

10. Cone RA, et al. Vaginal microbicides: detecting toxicities in vivo that paradoxically increase pathogen transmission. BMC Infect Dis 2006; 6: 90.

11. Gupta G. Microbicidal spermicide or spermicidal microbicide? Eur J Contracept Reprod Health Care 2005; 10: 212–218.

12. Aktualizace doporučených postupů CDC pro léčbu pohlavně přenosných chorob. Komentář: Čepický P. Gynek po prom 2003; 3: 32–40.

13. Ingram MJ, et al. A potential anti-implantation and spermicidal strategy: putative derivatives of nonoxynol-9 and anti-inflammatory agents and their spermicidal activity. Eur J Contracept Reprod Health Care 2006; 11: 258–261.

14. Ballagh SA, et al. Safety of single daily use for one week of C31G HEC gel in women. Contraception 2002; 66: 369–375.

15. Witherell GW. Glyminox Biosyn. Curr Opin Invest Drugs 2004; 5: 222–231.

16. Ramalho-Santos J, et al. Modulating sperm function for contraception: a multilayered challenge. Eur J Contracept Reprod Health Care 2012; 17: S6.

17. Kumar L, et al. Imidazole derivatives as possible microbicides with dual protection. Eur J Med Chem 2010; 45: 817–824.

18. Jain A, et al. Novel trichomonacidal spermicides. Antimicrob Agents Chemother 2011; 55: 4343–4351.

19. Weber J, et al. „Chemical condoms“ for the prevention of HIV infection: evaluation of novel agents against SHIV (89.6PD) in vitro and in vivo. AIDS 2001; 15: 1563–1568.

20. Dvořáčková K, et al. Mikrobicidy v lékových formách. Remedia 2008; 18: 181–184.

21. Sitruk-Ware R, et al. Vaginal rings for contraception. Eur J Contracept Reprod Health Care 2012; 17: S12–S13.

Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management
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