Diabetes mellitus, antidiabetics and bone
Authors:
Štěpán Svačina
Authors‘ workplace:
Univerzita Karlova v Praze, 1. lékařská fakulta, III. interní klinika VFN
Published in:
Čas. Lék. čes. 2010; 149: 282-284
Category:
Review Article
Overview
A short review of current opinions on a questionable and controversial disease – diabetic osteopathy – is presented. Bone metabolism is influenced by antidiabetic drugs. Positive effects are attributed to the insulin and metformin therapy. Use of thiazolidindiones is accompanied by a higher risk of bone fractures in diabetic women. Very interesting and also promising is the effect of glucagon like peptide-1 and the new antidiabetic drug class- incretin analogues on bone metabolism.
Key words:
diabetic osteopathy, thiazolidindiones, glucagon like peptid-1, incretin analogues.
Sources
1. Fisman EZ, Tenenbaum A. (eds.) Cardivascular diabetology. Advances in kardiology vo. 45. Basel: Karger 2008.
2. Pickup JC, Williams G. (eds.) Textbook of diabetes. Blackwell 2004; kap. 61.10.
3. Adami S. Bone health in diabetes: considerations for clinical management. Curr Med Res Opin 2009; 25(5): 1057–1072.
4. Strotmeyer ES, et al. Nontraumatic fracture risk with diabetes mellitus and impaired fasting glucose in older white and black adults: the health, aging, and body composition study. Arch Intern Med 2005; 165(14): 1612–1617.
5. Strotmeyer ES, et al. Diabetes is associated independently of body composition with BMD and bone volume in older white and black men and women: The Health, Aging, and Body Composition Study. J Bone Miner Res 2004; 19(7): 1084–1091.
6. Fantuzzi G, Mazzone Th. (eds.) Adipose tissue in health and disease. Totowa: Humana Press 2007.
7. Palička V. Léky ovlivňující kostní metabolismus u diabetiků. Vnitr Lek 2009; 55(4): 368–370.
8. Gao Y, Li Y, Xue J, Jia Y, Hu J. Effect of the anti-diabetic drug metformin on bone mass in ovariectomized rats. Eur J Pharmacol 2010; 19. E-pub.
9. Kahn SE, et al. Rosiglitazone-associated fractures in type 2 diabetes: an Analysis from A Diabetes Outcome Progression Trial (ADOPT). Diabetes Care 2008; 31(5): 845–851.
10. Zinman B, et al: Effect of rosiglitazone, metformin, and glyburide on bone biomarkers in patients with type 2 diabetes. J Clin Endocrinol Metab 2010; 95(1): 134–142.
11. Douglas IJ, Evans SJ, Pocock S, Smeeth L. The risk of fractures associated with thiazolidinediones: a self-controlled case-series study. PLoS Med 2009; 6(9): e1000154.
12. Meier C, et al. Use of thiazolidinediones and fracture risk. Arch Intern Med 2008; 168(8): 820–825.
13. Jones SG, Momin SR, Good MW, Shea TK, Patric K. Distal upper and lower limb fractures associated with thiazolidinedione use. Am J Manag Care 2009; 15(8): 491–496.
14. Haluzík M, Svačina Š. Inkretinová léčba diabetu. Praha: Mladá fronta 2010.
15. Bjerre Knudsen L, et al. Glucagon-like Peptide-1 receptor agonists activate rodent thyroid C-cells causing calcitonin release and C-cell proliferation. Endocrinology 2010; 151(4): 1473–1486.
16. Parks M, Rosebraugh C. Weighing risks and benefits of liraglutide – the FDA‘s review of a new antidiabetic therapy. N Engl J Med 2010; 362(9): 774–777.
17. Yamada C, et al. The murine glucagon-like peptide-1 receptor is essential for control of bone resorption. Endocrinology 2008; 149(2): 574–579.
18. Borm AK. The effect of pramlintide (amylin analogue) treatment on bone metabolism and bone density in patients with type 1 diabetes mellitus. Horm Metab Res 1999; 31(8): 472–475.
Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain managementArticle was published in
Journal of Czech Physicians
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