Renin, prorenin, and the direct renin inhibitor aliskiren
Authors:
Adolf Slabý; Aleš Žák
Authors‘ workplace:
Univerzita Karlova v Praze, 1. lékařská fakulta, IV. interní klinika VFN
Published in:
Čas. Lék. čes. 2010; 149: 55-60
Category:
Review Article
Overview
The renin-angiotensin system plays an important role in various physiological and pathophysiological regulatory mechanisms. Within the past few years, the classical concept of a linear enzymatic cascade has experienced substantial changes. A parallel counter-regulatory axis has been identified which involves the angiotensin converting enzyme homologue ACE2, angiotensin (1–7), and receptors Mas. The research in prorenin and its non-proteolytic activation has greatly advanced after the discovery of cellular receptors (P)RR; binding of renin or prorenin to these receptors not only facilitates angiotensin generation, but at the same time activates specific signal transduction pathways. The long-term search for clinically useful direct renin inhibitors has recently succeeded with the new antihypertensive drug aliskiren. While beneficial effects of aliskiren on some markers of cardiovascular and renal diseases have been proved in large clinical studies, important questions remain to be solved.
Key words:
renin-angiotensin system, ACE2 – angiotensin (1–7) – receptors Mas axis, nonproteolytic activation of prorenin, receptors (P)RR, direct renin inhibitor aliskiren.
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Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain managementArticle was published in
Journal of Czech Physicians
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