Male fertility and cancer treatment
Authors:
Jiří Heráček 1,2; Vladimír Sobotka 1,2,3; Eva Kindlová 2,4; Václav Eis 2,5; Michael Urban 1,2
Authors‘ workplace:
Univerzita Karlova v Praze, 3. lékařská fakulta, Urologická klinika
1; Fakultní nemocnice Královské Vinohrady, Praha
2; Pronatal, Praha
3; Univerzita Karlova v Praze, 3. lékařská fakulta, Radioterapeutická a onkologická klinika
4; Univerzita Karlova v Praze, 3. lékařská fakulta, Ústav patologie
5
Published in:
Čas. Lék. čes. 2010; 149: 16-20
Category:
Review Article
Overview
Approximately 15% of men with newly diagnosed cancer are younger than 55 years, and about 26% of them are younger than 20 years. However the most common cause of fertility disorders is oncological treatment itself, the oncological diseases, changes in anatomy, and primary or secondary hormonal insufficiency are also significant factors. The chemotherapy, radiation, or their combination reduce sperm count, impair sperm motility and cause disorders in morphology and DNA integrity. Prognosis of sperm production recovery depends on the type of cancer, stage of the disease, patient age, drug treatment, treatment route and dosage, and pre-treatment male fertility.
Key words:
male infertility, cancer, chemotherapy, radiotherapy, gonadotoxicity, spermatogenesis.
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Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain managementArticle was published in
Journal of Czech Physicians
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