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Interstitial Microdialysis in the Clinical and Experimental Medicine


Authors: M. Pojar;  J. Manďák
Authors‘ workplace: Kardiochirurgická klinika LF UK a FN, Hradec Králové
Published in: Čas. Lék. čes. 2006; 145: 766-770
Category: Review Article

Overview

Interstitial microdialysis is a minimally invasive method that allows biochemical monitoring of endogenous and exogenous substances in extracellular tissue space. The method is based on sampling of soluble molecules from the interstitial space fluid by means of a semipermeable membrane. Microdialysis has been applied in primary and clinical research of metabolic changes and the blood flow in tissue interstitium and pharmacokinetic drug studies. Results obtained by microdialysis are gradually finding their place in clinical practice as well. This paper is aimed at presenting to the reader new technique of monitoring interstitial metabolism, its advantages, drawbacks and relevance for medicine. 

Key words:
interstitial microdialysis, metabolism, recovery, primary research, cardiac surgery.


Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management
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