Authors: J. Petrák Authors‘ workplace: Ústav hematologie a krevní transfuze, Praha Published in: Čas. Lék. čes. 2005; 144: 365-370 Category: Review Article
Proteomics is a new methodological and conceptual approach to the study of live systems, which aims to map the whole proteom - the protein complement of genome. It aspires to describe quantitatively and qualitatively all proteins present at the given moment in the cell, tissue or the organism. The principal tools of proteomics are separation techniques based on electrophoresis and chromatography, which are used to fractionate complex protein mixtures and namely the mass spectrometry used for the identification of individual proteins. Proteomics represents very young and rapid developing specialization, which has already proved its valuable potential for the study of various physiological and pathlogical molecular mechanisms and for the direct use in the diagnostics of serious diseases.
Key words: proteomics, proteome, two-dimensional electrophoresis, chromatography, mass spectrometry.
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