Authors: M. Halačová; R. Průša; K. Kotaška; V. Vávrová 1 Authors‘ workplace: Ústav klinické biochemie a patobiochemie 2. LF UK a FNM, Praha 1II. dětská klinika 2. LF UK a FNM, Praha Published in: Čas. Lék. čes. 2004; : 187-190 Category:
Background. Once-daily administration of aminoglykosides is routinely used, but comparative efficacy data forpatients with cystic fibrosis are not available.Methods and Results. The aim of the this study was to compare the predicted pharmacodynamic (PD) activity ofamikacin at 28 mg/kg/den administered every 24 hod.(q24 h), q12 h, and q8 h. Pharmacokinetic (PK) data werederived from analysis of the amikacin serumconcentration from42 CF children patients. Individual pharmacokineticsvalues were used to construct serum concentration-versus time curves and to determine various indices (c peak/MICratio and time during the concentration was less than theMIC – T
Key words: cystic fibrosis, amikacin, pharmacokinetic parameters, MIC.
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