Authors: I. Matl; O. Viklický Authors‘ workplace: Klinika nefrologie Transplantcentra IKEM, Praha Published in: Čas. Lék. čes. 2002; : 601-605 Category:
Transformation growth factor (TGF-beta) is a cytokine, which takes part in many clinical conditions linked todifferent chronic disease states. Its production is regulated by genes and polymorphism of TGF-beta gene individuallypredetermines levels of its production. TGF-beta is produced by a number of normal, predominately haemopoieticand tissue cells. Moreover, it controls cell proliferation and differentiation, and namely it stimulates fibrogenesis.Profibrogenic efficacy plays a physiological role in wound healing and it is implicated in a spectrum of disease states,such as diabetic nephropathy, chronic glomerulonepthritis, lung fibrosis, or postirradiation fibrosis. In kidneytransplant recipients, TGF-beta has been suggested to be involved in the chronic rejection pathogenesis by enhancingfibrogenesis.
Key words: cytokines, extracellular matrix, fibrogenesis, glomerulonephritis, chronic rejection, cyclosporin,losartan.
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