Derivatives of Dehydroepiandrosterone in Obese and Their Changes During One-Day Starvation Test

Overview

Background.
Relationship between dehydroepiandrosterone (DHEA), its sulphate (DHEAS) and various components of metabolic syndrome X have been recently discussed in several papers. Original only DHEA or DHEAS have been considered to be responsible for all of the effects. At present mainly DHEA hydroxyderivatives (particularly 7-hydroxyisometers) are assumed to be responsible for those effects.Methods and Results. 68 obese subjects (28 males) aged 42.6±11.1 years, with average BMI 35.7±11.6 kg/m2 were examined. Relationship between 7-alpha and 7-beta-(OH)-DHEA and various components of metabolic syndrome X have been followed in a pilot epidemiological study. Fluctuations of the hydroxyderivates level during one-day starvation test were investigated in a group of 11 obese females and compared with that of the control group (12 lean subjects with BMI 23.1±2.4 kg/m2). From the view of the metabolic syndrome X, the negative correlation between the serum levels of 7-beta-(OH)-DHEA and insulinemia (R=-0.28; p=0.23), glycemia (r=-0,48; p

Key words:
dehydroepiandrosterone, 7-hydroxyderivatives of DHEA, metabolic syndrome X, one-day starvation