Dynamic Testing of Liver Function Using Lidocaine Test

Authors: K. Šídlová;  R. Průša
Authors‘ workplace: Ústav klinické biochemie a patobiochemie, Praha
Published in: Čas. Lék. čes. 2000; : 603-604


Lidocaine clearance test may reflect the integrity of various oxidative pathways of hepatocytes. Lidocaine isa highly sensitive indicator of hepatic dysfunction. This test is applicable to assessment of stage and prognosis ofthe liver disease, to timing of the liver transplantation, and to assessment of the pretransplant prognosis in the end-stageof chronic liver disease. Formation of the major lidocain metabolite monoethylglycinexylidide (MRGX) depends onthe hepatic cytochrome P-450 activity and on the liver blood flow.

Key words:
lidocaine, monoethylglycinexylidide, liver function, liver transplantation.

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