Dynamic Testing of Liver Function Using Lidocaine Test
Authors:
K. Šídlová; R. Průša
Authors‘ workplace:
Ústav klinické biochemie a patobiochemie, Praha
Published in:
Čas. Lék. čes. 2000; : 603-604
Category:
Overview
Lidocaine clearance test may reflect the integrity of various oxidative pathways of hepatocytes. Lidocaine isa highly sensitive indicator of hepatic dysfunction. This test is applicable to assessment of stage and prognosis ofthe liver disease, to timing of the liver transplantation, and to assessment of the pretransplant prognosis in the end-stageof chronic liver disease. Formation of the major lidocain metabolite monoethylglycinexylidide (MRGX) depends onthe hepatic cytochrome P-450 activity and on the liver blood flow.
Key words:
lidocaine, monoethylglycinexylidide, liver function, liver transplantation.
Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain managementArticle was published in
Journal of Czech Physicians
Most read in this issue
- Dynamic Testing of Liver Function Using Lidocaine Test
- Autoantibodies Against GAD65, IA-2 and Insulin in Czech Childrenat Type 1 Diabetes Mellitus Onset
- Atypical Form of Food Intake Disorder, a Diagnostic and Therapeutic Problem?
- Antioxidative Properties of Ascorbic Acid