Authors: T. Seeman; H. Vondřichová 1; J. Střížová 2; M. Šikut 1; J. Janda 1; K. Schärer 3 Authors‘ workplace: I. dětská klinika 2. LF UK, FN v Motole, Praha1 Klinika zobrazovacích metod 2. LF UK, FN v Motole, Praha 2 Oddělení klinické biochemie 2. LF UK, FN v Motole, Praha 3 Sekce pediatrické nefrologie Univerzitní dětské kliniky Heidelberg, SRN Published in: Čas. Lék. čes. 1999; : 178-184 Category:
Background. Autosomal dominant polycystic kidney disease is one of the most common inherited disorders witha prevalence of 1 : 1000 and is responsible for cca 10 % of end-stage renal disease in adult patients. Renal insufficiencyis a rare symptom of ADPKD in children, however, there are some symptoms, which can occur already in childhood.The aim of this study was to detect early signs of renal damage and to reveal the blood pressure profile in childrenwith ADPKD using ABPM (ambulatory blood pressure monitoring).Methods and Results. 32 children (aged 3.4-19.4 years, mean age 12.3) - carriers of PKD - gene with normalGFR, diagnosed on the basis of a positive family history and characteristic ultrasound features, and in 21 cases alsoindirect DNA analysis revealed positive results.11/32 children (34 %) presented arterial hypertension detected by ABPM (values higher than 95th centile of normalindividuals). The mean of ABPM values of all patients was significantly higher than normal children (p
Key words: autosomal dominant polycystic kidney disease, ABPM, hypertension, early renal damage.
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